李竹君;王晨羽;龙笑;
LI Zhujun;WANG Chenyu;LONG Xiao;Department of Plastic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine;

• 1:中国医学科学院北京协和医院整形美容外科
• 2:中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室
• 3:上海交通大学医学院附属第九人民医院整复外科

摘要(Abstract)：

间充质干细胞是具有自我更新和多向分化潜能的成体干细胞，存在于脂肪、骨髓和脐带等多种组织中，能通过直接分化或旁分泌的方式发挥修复组织缺损、促进血管生成、免疫调节、抗纤维化等多种作用。间充质干细胞在抗衰老、毛发/组织再生、创面愈合、抗纤维化等多个方面已有较为深入的研究，效果与安全性良好。未来仍需开展深入的基础研究以揭示其治疗机制，并进行长期的临床试验随访以考察其远期安全性。
Mesenchymal stem cells(MSCs) are adult stem cells that possess the ability of self-renewal and multi-lineage differentiation. They can be found in multiple tissue types, including adipose tissue, bone marrow and umbilical cord. MSCs can exert the effects of tissue repair, angiogenesis, immunoregulation, and anti-fibrosis through differentiation or paracrine function. Promising therapeutic effects of MSCs on skin aging, alopecia, tissue regeneration, wound healing, and anti-fibrosis have been observed. In general, MSCs exhibit favorable therapeutic effects and safety, but scrutinized research and clinical trials are still needed to reveal the mechanism of action as well as long-term efficacy and safety.

关键词(KeyWords)： 间充质干细胞;整形手术;美容;组织再生
mesenchymal stem cells;plastic surgery;cosmetic;tissue regeneration

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划(2020YFE0201600);; 中国医学科学院医学与健康科技创新工程(2020-I2M-C&T-A-004)~~

作者(Authors): 李竹君;王晨羽;龙笑;
LI Zhujun;WANG Chenyu;LONG Xiao;Department of Plastic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine;

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