华法林的发现史:从灭鼠药到救命药
张路;
摘要(Abstract)：
<正>在过去的近半个世纪,华法林一直是口服抗凝药物的代表和支柱,广泛用于血栓栓塞性疾病、心房纤颤、人工瓣膜置换术后等领域,是口服抗凝药物中的"霸主"。据统计,每100个英国人,至少有1人长期使用华法林[1],而在老年患者中比例更高。但随着达比加群酯、利伐沙班等新型口服抗凝药物的出现,可以为患者提供更安全和方便的治疗,华
关键词(KeyWords)：
华法林;抗凝药物;甜苜蓿病
基金项目(Foundation):
作者(Authors):
张路;
参考文献(References)：
- [1]Pirmohamed M.Warfarin:almost 60 years old and still causing problems[J].Br J Clin Pharmacol,2006,62:509-511.
- [2]Patel MR,Mahaffey KW,Garg J,et al.Rivaroxaban versus warfarin in nonvalvular atrial fibrillation[J].N Engl J Med,2011,365:883-891.
- [3]Schofield FW.Damaged sweet clover:the cause of a new disease in cattle stimulating hemorrhagic septicaemia and blackleg[J].J Am Vet Med Assoc,1924,64:553-575.
- [4]https://commons.wikimedia.org/wiki/File:Volunteers_of_America_Soup_Kitchen_WDC.gif?uselang=zh-cn.
- [5]Burris RH.Karl paul link[M]//Burris RH.Biographical Memoirs V.64.Washington DC:National Academy Press,1994:175-195.
- [6]Wardrop D,Keeling D.The story of the discovery of heparin and warfarin[J].Br J Haematol,2008,141:757-763.
- [7]Petit DW,Berne CJ.Medical progress:DICUMAROL[J].Calif Med,1947,67:40-44.
- [8]https://commons.wikimedia.org/wiki/Category:Warfarin#/media/File:Warfarin_ball-and-stick_model.png.