李默晗;孙丰润;王涛;贺渝淼;马超;黄宇光;
LI Mohan;SUN Fengrun;WANG Tao;HE Yumiao;MA Chao;HUANG Yuguang;Department of Anesthesiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Joint Laboratory of Anesthesia and Pain,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Human Anatomy,Histology and Embryology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Un

• 1:中国医学科学院北京协和医院麻醉科
• 2:中国医学科学院北京协和医院麻醉-疼痛联合实验室
• 3:中国医学科学院基础医学研究所北京协和医学院基础学院人体解剖与组织胚胎学系

摘要(Abstract)：

术中麻醉根据麻醉药物分布范围可分为全身麻醉和局部麻醉，其中局部麻醉在整形美容手术中的应用较为广泛。传统剂型经皮递送局麻药作用时间较短，且脂溶性差，限制了其在体表透皮方面的应用。近年来，随着麻醉技术的发展，新型体表镇痛局麻药递送系统可将涂抹于皮肤的药物递送至真皮层以阻滞神经末梢痛觉传入，从而达到镇痛的效果，提高了药物递送效率。此外，透皮给药相较于注射给药可显著增加给药安全性和患者舒适度。本文概述了常用的局麻药透皮吸收促进方法以及目前已上市的透皮局麻药物，并结合研究进展对局部麻醉透皮技术在整形美容手术中的应用和发展作一展望。
Intraoperative anesthesia can be divided into general anesthesia and local anesthesia according to the distribution of anesthetic drugs, and local anesthesia has broad applications in plastic surgery. The short acting time and poor lipid solubility of local anesthetics on conventional dosage limit their application in transdermal delivery. In recent years, there has been rapid developments in the topical analgesic transdermal delivery system, through which a drug penetrates the cuticle of the skin and enters the dermis to block the introduction of nerve terminal pain, so as to achieve the analgesic effect. In addition, transdermal administration can significantly increase safety and patient comfort compared to injectable administration. In this review, the commonly used methods of promoting transdermal absorption and topical analgesics on the market were overviewed, and the application and future direction of anesthetics in plastic and cosmetic surgerywere prospected based on the research progress.

关键词(KeyWords)： 局部麻醉;体表麻醉药;透皮递药系统;整形美容手术
local anesthetics;topical analgesics;transdermal drug delivery;plastic and cosmetic surgery

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81771205)~~

作者(Authors): 李默晗;孙丰润;王涛;贺渝淼;马超;黄宇光;
LI Mohan;SUN Fengrun;WANG Tao;HE Yumiao;MA Chao;HUANG Yuguang;Department of Anesthesiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Joint Laboratory of Anesthesia and Pain,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Human Anatomy,Histology and Embryology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Un

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