协和医学杂志

2020, v.11(02) 174-180

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乳糜泻诊断技术进展
Progress in Diagnostic Techniques for Celiac Disease

李融融;严婧文;柳思华;吴东;
LI Rong-rong;YAN Jing-wen;LIU Si-hua;WU Dong;Department of Clinical Nutrition,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Clinical Medical School,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

乳糜泻是一种在遗传易感人群中因摄入含麦胶食物而引起的慢性自身免疫性肠道炎症。目前,随着检测技术的迅速发展及人们对于乳糜泻的认识加深,血清抗体、遗传风险以及小肠组织病理已联合应用于诊断乳糜泻。本文回顾乳糜泻诊断技术的进展及争议,以期提高读者对于乳糜泻诊断的认识。
Celiac disease is an immune-mediated intestinal disorder characterized by chronic inflammation of the small intestine, triggered and maintained by exposure to gluten in the diet. The rapid development of technology and a better understanding of the mechanism of celiac disease lead to combining the application of new serologic diagnostic tests, certain genetic markers, and histopathologic evaluation to aid the diagnosis of celiac disease. We reviewed the recent progress and debate of the diagnostic techniques for celiac disease.

关键词(KeyWords): 麦胶性肠病;乳糜泻;诊断;血清学抗体;病理;遗传风险
gluten enteropathy;celiac disease;diagnosis;serological antibodies;pathology;genetic risk

Abstract:

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基金项目(Foundation): 北京协和医学院研究生教育教学改革项目(100232017);北京协和医学院中央高校基本科研业务费项目青年教师项目(3332018014)

作者(Author): 李融融;严婧文;柳思华;吴东;
LI Rong-rong;YAN Jing-wen;LIU Si-hua;WU Dong;Department of Clinical Nutrition,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Clinical Medical School,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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