协和医学杂志

2019, v.10(06) 666-672

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成纤维细胞生长因子受体1在非小细胞肺癌中的研究进展
Fibroblast Growth Factor Receptor 1 in Non-small Cell Lung Cancer

刘磊;张家齐;王桂阁;黄诚;李力;梁乃新;李单青;
LIU Lei;ZHANG Jia-qi;WANG Gui-ge;HUANG Cheng;LI Li;LIANG Nai-xin;LI Shan-qing;Department of Thoracic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

非小细胞肺癌(non-small cell lung cancer,NSCLC)已成为全世界癌症患者死亡的主要原因之一,其治疗成为目前研究热点。但NSCLC中成纤维细胞生长因子受体(fibroblast growth factor receptor,FGFR)基因突变以及间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合基因发生率低,相应靶向药物治疗的总体效果并不理想。FGFR1作为NSCLC中较常见的异常基因,其异常扩增高表达与多种肿瘤的发生发展相关,同时发现多种相关的分子靶向药物对肿瘤有抑制作用。本文对FGFR1在NSCLC中的扩增高表达情况、其与NSCLC临床特点之间的关系以及目前相关靶向药物治疗研究进展作一综述。
Non-small cell lung cancer( NSCLC) has become one of the leading causes of death by cancer in the world. Research on the treatment of lung cancer has become a hot spot. The incidence of fibroblast growth factor receptor( FGFR) gene mutation and anaplastic lymphoma kinase gene fusion in NSCLC is low,and the curative effect of corresponding targeted drug treatment is not satisfactory. FGFR1 is a common abnormal gene in non-small cell lung cancer. Recent study gradually found its abnormal amplification in various tumors,and also found that various related molecular-targeting drugs have an inhibitory effect on the corresponding tumor. This paper reviews the expression of FGFR1 in non-small cell lung cancer,its relationship with the clinical characteristics of NSCLC, and current research progress in targeted drug therapy.

关键词(KeyWords): 成纤维细胞生长因子受体1;非小细胞肺癌;临床特点;靶向治疗
fibroblast growth factor receptor 1;non-small cell lung cancer;clinical features;targeted therapy

Abstract:

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基金项目(Foundation): 教育部科学研究重大项目(311037)

作者(Author): 刘磊;张家齐;王桂阁;黄诚;李力;梁乃新;李单青;
LIU Lei;ZHANG Jia-qi;WANG Gui-ge;HUANG Cheng;LI Li;LIANG Nai-xin;LI Shan-qing;Department of Thoracic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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