协和医学杂志

2019, v.10(05) 505-513

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格特隐球菌基因组学研究进展
Advances in Genomic Research of Cryptococcus Gattii

贾鑫淼;肖盟;孙天舒;徐英春;
JIA Xin-miao;XIAO Meng;SUN Tian-shu;XU Ying-chun;Central Research Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases;Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

格特隐球菌属于新生隐球菌复合体,既往被认为是新生隐球菌复合体的变种,但最终被确立为独立的物种。与新生隐球菌不同,格特隐球菌多感染免疫力正常人群,目前致病机制尚未明确。格特隐球菌的基因组学研究不仅可全面了解其基因组成、分子进化、毒力因子以及致病机制等特点,还可对致病相关基因和重要蛋白进行预测,为疫苗和新型抗生素的研发提供分子基础,并进一步为高效治疗和防控隐球菌病提供理论依据。本文就格特隐球菌的基因组测序和基本特征、基因组进化、重要毒力基因以及比较基因组研究予以概述。
Cyptococcus gattii( C. gattii) belongs to the Cryptococcus neoformans complex and was previously considered to be a variant of the Cryptococcus neoformans complex( C. neoformans var. gattii)but eventually established as a separate species. Unlike C. neoformans,C. gattii predominantly infects immunocompetent persons. The pathogenic mechanism of C. gattii is not yet clear. The genomic research of C. gattii can not only comprehensively characterize the genetic composition,molecular evolution,virulence factors and pathogenic mechanisms,but also be used for the prediction of pathogenic genes and important proteins,which further facilitates the development of vaccines and new antibiotics and the construction of new effective treatments and prevention strategies against cryptococcosis. In this paper,the whole genome sequencing,genome features,genomic evolution,important virulence factors,and comparative genomic researches are reviewed.

关键词(KeyWords): 格特隐球菌;基因组;比较基因组;进化;感染毒力
Cyptococcus gattii;genome;comparative genome;evolution;pathogenicity

Abstract:

Keywords:

基金项目(Foundation): 北京市自然科学基金(5184037);; 中央高校基本科研业务费专项资金(3332018024);; “十三五”国家科技重大专项(2018ZX10712001);; 河北省科技计划项目(17277775D)

作者(Author): 贾鑫淼;肖盟;孙天舒;徐英春;
JIA Xin-miao;XIAO Meng;SUN Tian-shu;XU Ying-chun;Central Research Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases;Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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