协和医学杂志

2020, v.11(03) 276-282

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提高对儿童系统性红斑狼疮的认识
Improving the Acknowledge of Childhood-onset Systemic Lupus Erythematosus

邓江红;李彩凤;
DENG Jiang-hong;LI Cai-feng;Department of Rheumatology, Beijing Children's Hospital, Capital Medical University,National Center for Children's Health;

摘要(Abstract):

儿童系统性红斑狼疮(childhood-onset systemic lupus erythematosus,cSLE)特指在18岁之前发病的SLE,在我国小儿全身性结缔组织病中居第二位。与成人SLE相比,cSLE在流行病学、临床表现及治疗方面都有其自身特点。近年来,随着人类基因组学和分子生物学的迅猛发展,对该病的认识也在不断加深,本文对cSLE的病因、表现及治疗最新进展进行梳理和总结,以期更好地认识该病,进而指导临床实践。
Childhood-onset systemic lupus erythematosus(cSLE), which refers to SLE before the age of 18, is the second systemic connective tissue disease in children. Compared with adults, cSLE has its own characteristics in epidemiology, clinical presentation, and treatment. In recent years, with the rapid development of human genomics and molecular biology, the understanding of the disease has been updated. This paper reviewed recent progress in the etiology, manifestation, and treatment of cSLE, so as to better understand this disease and guide clinical practice.

关键词(KeyWords): 儿童;系统性红斑狼疮;流行病学;临床表现;治疗
childhood;systemic lupus erythematosus;epidemiology;clinical manifestation;treatment

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作者(Author): 邓江红;李彩凤;
DENG Jiang-hong;LI Cai-feng;Department of Rheumatology, Beijing Children's Hospital, Capital Medical University,National Center for Children's Health;

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