协和医学杂志

2020, v.11(04) 383-388

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胰腺神经内分泌肿瘤肝转移的外科治疗
Surgical Treatment of Pancreatic Neuroendocrine Neoplasm with Liver Metastasis

邵成浩;彭俊峰;
SHAO Cheng-hao;PENG Jun-feng;Department of General Surgery and Pancreaticobiliary Surgery,Shanghai Changzheng Hospital,Naval Medical University;

摘要(Abstract):

胰腺神经内分泌肿瘤(pancreatic neuroendocrine neoplasm,pNEN)是一类比较少见的胰腺肿瘤,其发病率近年来呈上升趋势。pNEN肝转移的治疗需综合考虑其病理分级、肿瘤分期、肝转移负荷及肝外转移情况,在全面评估的基础上,开展多学科协作,制定最佳诊疗方案,以控制肿瘤生长、减小肿瘤负荷、控制激素过多分泌及相关并发症、延长患者生存期为主要目标。手术是治疗pNEN肝转移的有效手段,有助于改善pNEN肝转移患者的预后。本文结合文献综述和笔者的临床诊疗经验,阐述目前pNEN肝转移手术治疗需关注的问题,以为临床提供指导。
Pancreatic neuroendocrine neoplasm(pNEN) is a relatively rare type of pancreatic tumor, and its incidence has been on the rise in recent years. The treatment of pNEN with liver metastasis needs comprehensive consideration of its pathological grade, tumor stage, liver metastasis burden, and extrahepatic metastasis, etc. On the basis of comprehensive evaluation, multidisciplinary team is needed to formulate the best diagnosis and treatment plan,and the main goals are to control tumor growth, reduce tumor burden, control excessive hormone secretion and related complications, and prolong patient survival. Surgery is an effective treatment method for pNEN with liver metastasis, which helps to improve the prognosis of patients. Based on literature review and our experiences, this article elaborated the current major issues of concern, to provide a guide for surgical treatment of pNEN with liver metastasis.

关键词(KeyWords): 胰腺;神经内分泌肿瘤;肝转移瘤;手术
pancreas;neuroendocrine neoplasm;liver metastasis;surgery

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基金项目(Foundation): 上海市卫生计生系统优秀学科带头人(新百人计划)项目(2017BR040)

作者(Author): 邵成浩;彭俊峰;
SHAO Cheng-hao;PENG Jun-feng;Department of General Surgery and Pancreaticobiliary Surgery,Shanghai Changzheng Hospital,Naval Medical University;

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