协和医学杂志

2021, v.12(01) 73-79

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内脏脂肪组织在克罗恩病发病、诊断及治疗中的作用
The Role of Visceral Adipose Tissue in the Pathogenesis,Diagnosis,and Treatment of Crohn's Disease

陈博;阳惠湘;
CHEN Bo;YANG Hui-xiang;Department of Gastroenterology, Xiangya Hospital, Central South University;

摘要(Abstract):

克罗恩病(Crohn's disease,CD)是一种慢性炎性肉芽肿性疾病,多发于末端回肠和临近结肠,呈节段性分布。CD肠道病变的机制尚不完全明确,与遗传、免疫和环境等多种因素有关。脂肪组织在CD的发病中发挥重要作用,最新研究发现内脏脂肪组织(visceral adipose tissue,VAT),特别是其肠系膜成分,亦称为爬行脂肪,可通过免疫调节特性影响CD进程。本文主要综述VAT在CD发病、诊断及治疗中的研究进展,以期为临床诊疗提供理论依据。
Crohn's disease(CD) is a chronic inflammatory granulomatous disease, which usually occurs at the end of the ileum and adjacent colon with segmental distribution. The pathogenesis of CD's intestinal lesions is not completely clear, which is related to multiple factors such as heredity, immunity, and environment. Adipose tissue plays an important role in the pathogenesis of CD. Recently, it has been found that visceral adipose tissue(VAT), especially its mesenteric component, i.e. creeping fat, has an impact on the disease course through its immunomodulatory properties. This paper reviews the research progress of VAT in the pathogenesis, diagnosis, and treatment of CD, in order to provide theoretical basis for clinicians.

关键词(KeyWords): 内脏脂肪组织;爬行脂肪;克罗恩病;脂肪因子
visceral adipose tissue;creeping fat;Crohn's disease;adipokines

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基金项目(Foundation): 国家自然科学基金(81873585)~~

作者(Author): 陈博;阳惠湘;
CHEN Bo;YANG Hui-xiang;Department of Gastroenterology, Xiangya Hospital, Central South University;

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