协和医学杂志

2020, v.11(03) 258-263

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肠道菌群与系统性红斑狼疮
Gut Microbiota and Systemic Lupus Erythematosus

陈蓓迪;赵丽丹;张烜;
CHEN Bei-di;ZHAO Li-dan;ZHANG Xuan;Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases,Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以慢性炎症和多器官损害为特征的自身免疫性疾病,主要累及育龄期女性,目前尚无法根治。SLE病因不明,发病风险与遗传及环境因素相关。近年来研究表明,SLE患者存在肠道菌群组成和功能紊乱,继而可引起肠道屏障功能破坏、慢性炎症和自身免疫激活,这可能是SLE发生发展的重要机制。本文对这一领域的相关研究进展予以概述,探讨菌群干预作为SLE防治新策略的潜在应用价值,并对未来SLE相关肠道菌群研究的发展方向进行展望。
Systemic lupus erythematosus(SLE) is a common autoimmune disease characterized by chronic inflammation and multi-organ damage and mainly affects women of childbearing age. SLE can only be controlled but not cured currently. The occurrence and development of SLE were reported to be associated with genetic factors as well as environmental triggers. In recent years, mounting evidence showed that there were compositional and functional changes in the gut microbiota of SLE patients. Also, the disturbed gut microbiota was suggested to partake in SLE pathogenesis by damaging the gut barrier, as well as inducing or aggravating chronic inflammation and autoimmunity. This review summarized the progress of research on the gut microbiota in SLE, discussed the clinical value of gut microbiota-related interventions, and envisions the future direction of research related to gut microbiota in lupus.

关键词(KeyWords): 系统性红斑狼疮;肠道菌群;发病机制;菌群干预
systemic lupus erythematosus;gut microbiota;pathogenesis;microbiota-related intervention

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基金项目(Foundation): 国家自然科学基金(81788101、81630044);; 中国医学科学院医学与健康科技创新工程(2017-12M-1-008、2017-I2M-3-011、2016-12M-1-003、2016-12M-1-008)

作者(Author): 陈蓓迪;赵丽丹;张烜;
CHEN Bei-di;ZHAO Li-dan;ZHANG Xuan;Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases,Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College;

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