协和医学杂志

2017, v.8(Z2) 278-282

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CD8~+T淋巴细胞在原发性胆汁性胆管炎发病机制中的调控与作用
CD8~+T Cells in the Pathogenesis of Primary Biliary Cholangitis

陶葸茜;王立;张奉春;
TAO Xi-xi;WANG Li;ZHANG Feng-chun;Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Ultrasound,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

原发性胆汁性胆管炎(primary biliary cholangitis,PBC)是一种以肝脏损害为主要表现的自身免疫性疾病,其发病机制目前尚不明确,可能与多种因素相关。其中,在PBC的免疫功能紊乱中,CD8~+T淋巴细胞介导的细胞免疫有重要作用,与PBC患者肝脏胆管上皮细胞受损有关。本文主要讨论CD8~+T细胞在PBC发病机制中的调控及该群细胞对PBC肝脏的损害作用。
Primary biliary cholangitis( PBC) is an autoimmune disease characterized by the liver damage. The pathogenesis of PBC is not fully understood currently,and many factors are involved. The cellular immunity mediated by CD8~+T cells plays an important role in the immune dysregulation of PBC,which is related to the injury of biliary epithelial cells. This review is mainly about the regulation of CD8~+T cells that involves several mechanisms,and the function of this group of cells in the liver damage of PBC patients.

关键词(KeyWords): 原发性胆汁性胆管炎;CD8+T淋巴细胞;发病机制
primary biliary cholangitis;CD8+T cells;pathogenesis

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基金项目(Foundation): 国家自然科学基金面上项目(81571594);国家自然科学基金青年项目(81501414,81501410,81501413);; 首都卫生发展科研专项青年项目(2016-4-40111)

作者(Author): 陶葸茜;王立;张奉春;
TAO Xi-xi;WANG Li;ZHANG Feng-chun;Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Ultrasound,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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