协和医学杂志

2017, v.8(06) 381-386

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Meta-分析的方法学局限性及其适用领域
Methodological Limitations and Applicable Context of Meta-analysis

彭晓霞;
PENG Xiao-xia;Center for Clinical Epidemiology and Evidence-based Medicine,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health;

摘要(Abstract):

人群研究,尤其是临床研究需要重复,但重复研究往往会产生不一致的研究结果,采用系统综述及时综合分析同一问题相关研究便成为循证决策的基础,系统综述中可以对原始研究数据实现统计合并的Meta-分析已在越来越多领域得到广泛应用。但Meta-分析本身存在局限性,是否适用于所有类型研究的统计合并,尚存争议。有鉴于此,本文在介绍系统综述步骤和Meta-分析基本原理及统计合并计算步骤的基础上,进一步分析Meta-分析的误差来源,解释随机效应模型与固定效应模型的区别,旨在引导人们客观理解Meta-分析的方法学局限性,审慎使用Meta-分析,在进行临床决策时审慎解读Meta-分析结果,尤其是基于随机效应模型的统计合并。
Researches,especially population studies and clinical studies,need to be repeated. However,repeated studies on the same question may produce conflict results. Therefore,a systematic review,a timely comprehensive analysis of individual studies on the same question,is the basis of evidence-based decision making. Meta-analysis of systematic review,which is regarded as the method for producing the evidence of top level,has been widely used in more and more fields. However,there are some methodological limitations for meta-analysis. It is controversial whether meta-analysis could be applicable to all type of researches. In view of this fact,we introduced the procedure of systematic review,the basic principle and the statistical formula of meta-analysis,and further explored the sources of error in meta-analysis and explained the difference between the random effect model and the fixed effect model in order to understand the methodological limitations of meta-analysis and perform it deliberately.At the same time,we recommended that clinicians should carefully interpret the pooled results of a meta-analysis,especially of the one using the random effect model,when they are going to make a clinical decision.

关键词(KeyWords): 系统综述;Meta-分析;误差;随机效应模型;固定效应模型
systematic reviews;Meta-analysis;error;random effect model;fixed effect model

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作者(Author): 彭晓霞;
PENG Xiao-xia;Center for Clinical Epidemiology and Evidence-based Medicine,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health;

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