协和医学杂志

2020, v.11(03) 264-269

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神经精神性狼疮相关抗体及其诊断价值
Autoantibodies Involved in Neuropsychiatric Systemic Lupus Erythematosus and Its Diagnostic Value

尤含笑;李梦涛;张奉春;曾小峰;胡朝军;
YOU Han-xiao;LI Meng-tao;ZHANG Feng-chun;ZENG Xiao-feng;HU Chao-jun;Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases,Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

神经精神性狼疮(neuropsychiatric systemic lupus erythematosus,NPSLE)是系统性红斑狼疮(systemic lupus erythematosus,SLE)病变累及神经系统而产生神经和/或精神症状的一组预后差、死亡率高的严重并发症,SLE患者血清或脑脊液中检测到的独特的自身抗体与神经精神疾病相关。在SLE患者中,NPSLE的患病率从17%至75%不等。本文论述国内外最新研究结果,着重探讨抗核糖体P抗体、抗磷脂抗体、抗神经元抗体等相关抗体在中枢神经受累的NPSLE中的研究现状及其临床价值。
Neuropsychiatric systemic lupus erythematosus(NPSLE) is a group of severe complications with a poor prognosis and high mortality caused by systemic lupus erythematosus(SLE). Its lesions involve the nervous system and cause neurological and/or psychiatric symptoms. Unique autoantibodies detected in the serum or cerebrospinal fluid of patients with NPSLE are associated with the presence of neuropsychiatric disorders. The prevalence of NPSLE ranges from 17% to 75% in SLE. This article reviewed the latest progress and focused on the current state of knowledge and the potential clinical value of anti-ribosomal P antibody, antiphospholipid antibody, anti-neuronal antibody, and other related antibodies in NPSLE with central nervous involvement.

关键词(KeyWords): 系统性红斑狼疮;神经精神性狼疮;自身抗体
systemic lupus erythematosus;neuropsychiatric systemic lupus erythematosus;autoantibodies

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划(2019YFC0840603);; 国家自然科学基金(81771780);; 中国医学科学院医学与健康科技创新工程(2017-I2M-3-001)

作者(Author): 尤含笑;李梦涛;张奉春;曾小峰;胡朝军;
YOU Han-xiao;LI Meng-tao;ZHANG Feng-chun;ZENG Xiao-feng;HU Chao-jun;Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases,Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College;

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