协和医学杂志

2021, v.12(01) 129-135

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免疫检查点抑制剂相关甲状腺毒症
Thyrotoxicosis Related to Immune Checkpoint Inhibitors

武凌鸽;徐燕;李乃适;
WU Ling-ge;XU Yan;LI Nai-shi;Department of Endocrinology,Key Laboratory of Endocrinology,National Health Commission of the People's Republic of China,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Respiratory and Critical Care Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)是近年来恶性肿瘤治疗领域的一项重大突破。其通过针对T细胞的调节作用,增强抗肿瘤免疫反应,改善恶性肿瘤患者的预后,延长患者生存期,现已获批用于治疗多种肿瘤,但ICIs在应用过程中产生的甲状腺毒症是不容忽视的临床问题。本文对ICIs相关甲状腺毒症的发生机制、临床表现、处理对策等进行综述。
Immune checkpoint inhibitors(ICIs) have come out in recent years as a breakthrough of the treatments for malignant tumors by regulating T cells with the purpose of enhancing their anti-tumor response, which can improve prognosis and increase survival. However, thyrotoxicosis caused by ICIs has become a clinical problem that cannot be ignored. This review summarizes the pathogenic mechanisms, clinical manifesta-tions, and treatments of ICIs associated thyrotoxicosis.

关键词(KeyWords): 免疫检查点抑制剂;免疫相关不良反应;甲状腺毒症
immune checkpoint inhibitors;immune-related adverse events;thyrotoxicosis

Abstract:

Keywords:

基金项目(Foundation): 国家“十三五”重大新药创制专项子课题“创新药物临床评价示范性平台建设”(2019ZX09734001-002);; 中国医学科学院医学与健康科技创新工程重大协同创新项目(2017-I2M-1-009)~~

作者(Author): 武凌鸽;徐燕;李乃适;
WU Ling-ge;XU Yan;LI Nai-shi;Department of Endocrinology,Key Laboratory of Endocrinology,National Health Commission of the People's Republic of China,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Respiratory and Critical Care Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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