协和医学杂志

2019, v.10(04) 428-432

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绒毛膜癌的研究历程:从协和经验到国际典范
History of Research on Choriocarcinoma: from the Experience of Peking Union Medical College Hospital to the International Clinical Practice

向阳;
XIANG Yang;Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;

摘要(Abstract):

绒毛膜癌是一种高度恶性的妇科肿瘤,侵袭性高,早期可经血行转移至全身而成为全身性疾病。20世纪60年代前,因缺乏有效治疗方法,绒毛膜癌患者死亡率高达90%。1949年以来,在宋鸿钊院士带领下,北京协和医院对绒毛膜癌的发生、发展、诊断与治疗进行了一系列研究,并取得开创性成果。经团队不懈努力,将"死亡率90%以上"反转为"总体治愈率90%以上",极大推动了该领域学术水平的发展。目前我国在该领域研究中仍处于国际领先地位,北京协和医院经验得到国际同行认可并被写入国际指南。
Choriocarcinoma is a highly invasive malignant gynecological carcinoma. Widespread metastases can occur by bloodstream in the early stage. Before 1960 s,due to the lack of effective treatments,its mortality rate was above 90%. Since 1949,under the leadership of Academician SONG Hong-zhao,Peking Union Medical College Hospital has conducted a series of research on the pathogenesis,development,diagnosis and treatment of choriocarcinoma,and has achieved groundbreaking results. His team members are continuing to make unremitting efforts. Their work plays an important role in enhancing the research level in this field. Now,the overall cure rate of choriocarcinoma is over 90%. At present,China has maintained the cutting edge of this field. Efforts by Peking Union Medical College Hospital has been recognized by their overseas counterparts and written into the international guidelines of Choriocarcinoma.

关键词(KeyWords): 绒毛膜癌;化学药物治疗;生育功能;临床分期;耐药机制
choriocarcinoma;chemotherapy;reproductive function;clinical stage;drug resistance mechanism

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作者(Author): 向阳;
XIANG Yang;Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;

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