协和医学杂志

2020, v.11(02) 181-185

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自体胰岛移植的进展及现状研究
Current Status and Progress of Islet Auto-transplantation

柏钦正;王磊;
BAI Qin-zheng;WANG Lei;Department of General Surgery, Qilu Hospital of Shandong University;

摘要(Abstract):

部分或全部胰腺切除术后,患者常有糖耐量异常甚至糖尿病的发生。针对此类胰腺手术,将切除组织中的胰岛提取后自体移植以保护胰腺内分泌功能的方法逐渐受到重视。本文总结自体胰岛移植自1977年开展首例至今40余年的进展历程,包括胰岛分离提纯及移植技术的进步、术后效果特别是术后胰岛素不依赖率的改善以及该术式适应证的不断拓展,并对当前自体胰岛移植现状和所面临的困难进行论述,对其发展前景作出展望。
Generally,total or subtotal pancreatectomy induces an inevitable loss of partial or even all of the pancreas, which brings about impaired glucose tolerance and diabetes mellitus.To protect the pancreatic endocrine function, islet auto-transplantation from the resected pancreatic tissues has gradually been valued. This article reviews the 40-years progress of islet auto-transplantation since 1977 when the first case was reported, including the progress in the techniques of islet isolation, purification, and transplantation, improvement of postoperative insulin independency, and expansion of the indications. We also discuss the current status and the difficulty of islet auto-transplantation, and finally forecast its prospect.

关键词(KeyWords): 慢性胰腺炎;胰腺切除术;胰源型糖尿病;自体胰岛移植
chronic pancreatitis;pancreatectomy;pancreatogenic diabetes;islet auto-transplantation

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作者(Author): 柏钦正;王磊;
BAI Qin-zheng;WANG Lei;Department of General Surgery, Qilu Hospital of Shandong University;

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