协和医学杂志

2017, v.8(Z2) 289-293

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Musashi-2在恶性肿瘤发生发展及诊疗靶点中的作用
Role of Musashi-2 in the Occurrence and Development and as the Diagnostic and Therapeutic Target of Malignant Tumors

张苏杰;殷华奇;叶雄俊;徐涛;
ZHANG Su-jie;YIN Hua-qi;YE Xiong-jun;XU Tao;Department of Urology,Peking University People's Hospital;

摘要(Abstract):

Musashi-2(Msi-2)蛋白自发现以来,有关其在干细胞未分化状态和自我更新能力中发挥的作用一直是研究的热点,而近年来也证实Msi-2在恶性肿瘤的发生、发展中起到关键性作用,现有研究不仅仅局限于Msi-2促进恶性肿瘤发生发展的机制,Msi-2应用于恶性肿瘤诊断和个体化治疗的价值也日益凸显。本文将对Msi-2在恶性肿瘤发生发展中的作用及其作为诊断及治疗靶点的最新研究进展进行综述。
The role that Musashi-2( Msi-2) protein plays in maintaining the undifferentiated status and self-renewal ability of stem cells has been a hot issue since its discovery. In recent years,it has been confirmed that Msi-2 plays a key role in the development and progression of malignant tumors. The existing study is not limited to Msi-2's function in promoting the development of malignant tumor. The use of Msi-2 in the diagnosis of malignant tumors,and its value in individual treatment have become increasingly prominent. We will review the role of Msi-2 in the development of malignant tumors and its latest research progress as a diagnostic and therapeutic target.

关键词(KeyWords): Musashi-2;恶性肿瘤;干细胞;靶向治疗
Musashi-2;cancer;stem cell;targeted therapy

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作者(Author): 张苏杰;殷华奇;叶雄俊;徐涛;
ZHANG Su-jie;YIN Hua-qi;YE Xiong-jun;XU Tao;Department of Urology,Peking University People's Hospital;

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