高洋;孙昭;白春梅;
GAO Yang;SUN Zhao;BAI Chun-mei;Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

• 1:中国医学科学院北京协和医学院北京协和医院肿瘤内科

摘要(Abstract)：

胃癌是最常见的恶性肿瘤之一,其发病率与死亡率均呈较高水平。丙酮酸激酶M2(pyruvate kinase M2,PKM2)是糖酵解过程的关键限速酶,在多种肿瘤组织中表达明显升高,目前认为PKM2与肿瘤的发生、发展密切相关。在胃癌中,PKM2通过参与调节糖酵解途径、介导PI3K/Akt/mTOR信号通路活化、调控基因转录与细胞凋亡,进而促进胃癌细胞的增殖、转移,抑制细胞凋亡,最终加速胃癌的发展,本文将对此进行详细综述。
Gastric cancer is one of the most common malignant neoplasms with high morbidity and mortality. Pyruvate kinase M2(PKM2) is one of the key rate-limiting enzymes in glycolysis. The expression of PKM2 is significantly increased in a variety of tumors. It is currently considered that PKM2 is related to the development of tumors. PKM2 may promote the development of gastric cancer through the regulation of glycolysis, activation of PI3 K/Akt/mTOR and inhibition of apoptosis of tumor cells. Literature will be briefly summarized in this review.

关键词(KeyWords)： 胃癌;丙酮酸激酶M2;糖酵解;细胞凋亡
gastric cancer;pyruvate kinase M2;glycolysis;apoptosis

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 高洋;孙昭;白春梅;
GAO Yang;SUN Zhao;BAI Chun-mei;Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

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