胶原代谢与盆腔器官脱垂
李玢;朱兰;
摘要(Abstract):
<正>盆腔器官脱垂(pelvic organ prolapse,POP)是一个全球性的健康问题,影响着各个年龄段的妇女,并会降低患者的生活质量。盆底是由骨骼肌、平滑肌和结缔组织构成的复杂支持系统,肛提肌是主要的盆底肌,通过收缩对盆腔器官起到支持作用。
关键词(KeyWords):
盆腔器官脱垂;胶原代谢
基金项目(Foundation): 国家自然科学基金(30973180)
作者(Author):
李玢;朱兰;
Email:
DOI:
参考文献(References):
- [1]DeLancey JO.The anatomy of the pelvicfloor[J].Curr Opin Obstet Gynecol,1994,6:313-316.
- [2]Hendrix SL,Clark A,Nygaard I,et al.Pelvic organ pro-lapse in the Women s Health Initiative:gravity and gravidity[J].Am J Obstet Gynecol,2002,186:1160-1166.
- [3]Ramachandran G,Kartha G.Structure of collagen[J].Na-ture,1955,176:593-595.
- [4]Bailey AJ,Paul RG,Knott L.Mechanisms of maturation and ageing of collagen[J].Mech Ageing Dev,1998,106:1-56.
- [5]Paul RG,Bailey AJ.Glycation of collagen:the basis of its central role in the late complications of ageing and diabetes[J].Int J Biochem Cell Biol,1996,28:1297-1310.
- [6]Mott JD,Werb Z.Regulation of matrix biology by matrix metalloproteinases[J].CurrOpin Cell Biol,2004,16:558-564.
- [7]Chen B,Wen Y,Wang H,et al.Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1and matrix metalloproteinase-1expression in cultured fibro-blasts from continent and incontinent women[J].Am J Ob-stet Gynecol,2003,189:59-65.
- [8]Gomez DE,Alonso DF,Yoshiji H,et al.Tissue inhibitors of metalloproteinases:structure,regulation and biological functions[J].Eur J Cell Biol,1997,74:111-122.
- [9]Clark AL,Slayden OD,Hettrich K,et al.Estrogen increa-ses collagen I and IIImRNAexpression in the pelvic support tissues of the rhesus macaque[J].Am J Obstet Gynecol,2005,192:1523-1529.
- [10]Kremer EA,Chen Y,Suzuki K,et al.Hydroxyapatite in-duces autolytic degradation and inactivation of matrix metal-loproteinase-1and-3[J].J Bone Miner Res,1998,13:1890-1902.
- [11]Doillon CJ,Dunn MG,Bender E,et al.Collagenfiber for-mation in repair tissue:development of strength and tough-ness[J].Coll Relat Res,1985,5:481-492.
- [12]Birk DE.Type Vcollagen:heterotypic typeI/Vcollagen in-teractions in the regulation of fibril assembly[J].Micron,2001,32:223-237.
- [13]Birk DE,Fitch JM,Babiarz JP,et al.Collagen fibrillogene-sis in vitro:interaction of types I and Vcollagen regulates fi-bril diameter[J].J Cell Sci,1990,95(Pt4):649-657.
- [14]Niyibizi C,Eyre DR.Structural characteristics of cross-link-ing sites in type V collagen of bone.Chain specificities and heterotypic links to type I collagen[J].Eur J Biochem,1994,224:943-950.
- [15]Moalli PA,Talarico LC,Sung VW,et al.Impact of meno-pause on collagen sub-types in the arcus tendineous fasciae pelvis[J].Am J Obstet Gynecol,2004,190:620-627.
- [16]Gabriel B,Denschlag D,Gobel H,et al.Uterosacral liga-ment in women with or without pelvic organ prolapse[J].IntUrogynecol J Pelvic FloorDysfunct,2005,16:475-479.
- [17]Moalli PA,Shand SH,Zyczynski HM,etal.Remodeling of vaginal connective tissue in patients with prolapse[J].Ob-stet Gynecol,2005,106(5Pt1):953-963.
- [18]Ewies AA,Al-Azzawi F,Thompson J.Changes in extracel-lular matrix proteins in the cardinal ligaments of post-meno-pausal women with or without prolapse:a computerized im-munohistomorphometric analysis[J].Hum Reprod,2003,18:2189-2195.
- [19]Knuuti E,Kauppila S,Kotila V,et al.Genitourinary pro-lapse and jointhypermobility are associated with altered type I and III collagen metabolism[J].Arch Gynecol Obstet,2010[2010-07-08].http://www.springerlink.com/content/yu23746566524025/.DOI:10.1007/s00404-010-1518-x.
- [20]Jackson SR,Avery NC,Tarlton JF,et al.Changes in me-tabolism of collagen in genitourinary prolapse[J].Lancet,1996,347:1658-1661.
- [21]Gabriel B,Watermann D,Hancke K,et al.Increased ex-pression of matrix metal-loproteinase2in uterosacral liga-ments is associated with pelvic organ prolapse[J].Int Uro-gynecol J Pelvic Floor Dysfunct,2006,17:478-482.
- [22]Phillips CH,Anthony F,Benyon C,etal.Collagen metabo-lism in the uterosacral ligaments and vaginal skin of women with uterine prolapse[J].Br J ObstetGynaec,2006,113:39-46.
- [23]Strinic T,Vulic M,Tomic S,etal.Matrixmetalloproteinas-es-1,-2expression in uterosacral ligaments fromwomen with pelvic organ prolapse[J].Maturitas,2009,64:132-135.
- [24]Chen HY,Lin WY,Chen YH,et al.Matrix metalloprotein-ase-9polymorphism and risk of pelvic organ prolapse in Tai-wanese women[J].Eur J Obstet Gynecol Reprod Biol,2010,149:222-224.
- [25]Yamauchi M,Woodley DT,Mechanic GL.Aging and cross-linking of skin collagen[J].Biochem Biophys Res Com-mun,1988,152:898-903.
- [26]Kokcu A,Yanik F,Cetinkaya M,et al.Histopathological evaluation of the connective tissue of the vaginal fascia and the uterine ligaments in women with and withoutpelvic relax-ation[J].Arch Gynecol Obstet,2002,266:75-78.
- [27]Makinen J,SoderstromKO,Kiilholma P,etal.Histological changes in the vaginal connective tissue of patients with and without uterine prolapse[J].Arch Gynecol,1986,239:17-20.
- [28]Makinen J,Kahari VM,Soderstrom KO,et al.Collagen synthesis in the vaginal connective tissue of patients with and without uterine prolapse[J].Eur J Obstet Gynecol Reprod Biol,1987,24:319-325.
- [29]Poncet S,Meyer S,Richard C,et al.The expression and function of the endothelin system in contractile properties of vaginal myofibroblasts of women with uterovaginal prolapse[J].Am J Obstet Gynecol,2005,192:426-432.
- [30]Yamamoto M,Akazawa K,Aoyagi M,et al.Changes in bi-ological characteristics during the cellular aging of ligament fibroblasts derived from patients with prolapsus uteri[J].Mech Ageing Dev,2000,115:175-187.
- [31]Ewies AA,El-Shafie M,Li J,et al.Changes in transcrip-tion profile and cytoskeleton morphology in pelvic ligament fibroblasts in response to stretch—the effects of oestradiol and levormeloxifene[J].Mol HumReprod,2008,14:127-135.
- [32]Falconer C,Ekman-Ordeberg G,Ulmsten U,et al.Chan-ges in paraurethral connective tissue at menopause are coun-teracted by estrogen[J].Maturitas,1996,24:197-204.
- [33]Rizk DE,Hassan HA,AlMarzouqi AH,et al.Combined estrogen and ghrelin administration restores number of blood vessels and collagen type I/III ratio in the urethral and anal canal submucosa of old ovariectomized rats[J].Int Urogy-necol J Pelvic Floor Dysfunct,2008,19:547-552.
- [34]Zong WJ,Zyczynski HM,Meyn LA,et al.Regulation of MMP-1by sex steroid hormones in fibroblasts derived from the female pelvic floor[J].Am J Obstet Gynecol,2007,196:349.e1-11.
- [35]Liu YM,Choy KW,Lui WT,et al.17beta-estradiol sup-presses proliferation of fibroblasts derived from cardinal liga-ments in patients with or without pelvic organ prolapse[J].Hum Reprod,2006,21:303-308.