协和医学杂志

2020, v.11(04) 486-491

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胰高血糖素样肽-1受体PET/CT定位诊断胰岛素瘤的技术规范
Procedure Guideline of Glucagon-like Peptide- 1 Receptor Positron Emission Tomography/Computed Tomography in Localizing Insulinoma

罗亚平;李方;于淼;邢小平;张太平;赵玉沛;
LUO Ya-ping;LI Fang;YU Miao;XING Xiao-ping;ZHANG Tai-ping;ZHAO Yu-pei;Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine;Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;Department of General Surgery,Peking Union Medical College Hospital,Chinese

摘要(Abstract):

胰岛素瘤的诊断和手术治疗依赖于准确的影像学检查定位。以胰腺β细胞为靶点的胰高血糖素样肽-1受体(glucagon-like peptide-1 receptor, GLP-1R)是近年来胰岛素瘤影像研究中的亮点,推荐临床推广使用~(68)Ga-exendin-4进行GLP-1R正电子发射断层显像/计算机体层成像(positron emission tomography/computed tomography, PET/CT)来定位诊断胰岛素瘤。本文介绍GLP-1R显像在胰岛素瘤中的应用概况,并以~(68)Ga-exendin-4 GLP-1R PET/CT显像为例,介绍该技术的操作规范,以期为临床提供借鉴。
The diagnosis and surgical treatment of insulinoma is dependent on accurate localization with imaging modalities. Glucagon-like peptide-1 receptor(GLP-1 R) imaging that targets pancreatic β cells has been highlighted for detecting insulinomas in recent years. Since the high sensitivity and specificity(se. 99%, sp. 100%) of GLP-1 R imaging in localizing insulinoma, GLP-1 R positron emission tomography/computed tomography(PET/CT) with ~(68)Ga-exendin-4 is recommended to be introduced into clinical practice. This paper introduced the application of GLP-1 R imaging in insulinoma, and took the GLP-1 R PET/CT with ~(68)Ga-exendin-4 as an example to elaborate the operation standard of this technique, aiming to provide a reference for clinical practice.

关键词(KeyWords): 胰高血糖素样肽-1受体;~(68)Ga-exendin-4;胰岛素瘤;技术
glucagon-like peptide-1 receptor;68Ga-exendin-4;insulinoma;technology

Abstract:

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基金项目(Foundation): 国家自然科学基金(81501515);; 公益性行业科研专项(201402001)

作者(Author): 罗亚平;李方;于淼;邢小平;张太平;赵玉沛;
LUO Ya-ping;LI Fang;YU Miao;XING Xiao-ping;ZHANG Tai-ping;ZHAO Yu-pei;Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine;Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;Department of General Surgery,Peking Union Medical College Hospital,Chinese

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