协和医学杂志

2017, v.8(Z1) 179-183

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盆腔器官脱垂的遗传学研究
Genetic Study of Pelvic Organ Prolapse

王琦璞;朱兰;
WANG Qi-pu;ZHU Lan;Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Gynecology and Obstetrics,Peking Union Medical College Hospital;

摘要(Abstract):

盆腔器官脱垂(pelvic organ prolapse,POP)是中老年女性的常见病。POP的发生是遗传和环境共同作用的结果,遗传因素是其重要的危险因素之一。本文对POP相关的遗传学研究进行回顾,其中与结缔组织合成、降解相关的基因研究较多,但尚无明确结论,有待进一步探究。
Pelvic organ prolapse(POP) is a common disease in middle-aged and old women. Both genetic and environmental factors contribute to the development of POP. Predisposing hereditary factor is an important risk factor for POP. The latest progress of genetic research in POP will be discussed in this article. Most studies focused on genes involved in the synthesis and degradation of connective tissue. The genetics of POP remain to be further explored since no definitive conclusions have been reached so far.

关键词(KeyWords): 盆腔器官脱垂;患病率;危险因素;遗传
pelvic organ prolapse;prevalence;risk factors;genetic

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作者(Author): 王琦璞;朱兰;
WANG Qi-pu;ZHU Lan;Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Gynecology and Obstetrics,Peking Union Medical College Hospital;

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