协和医学杂志

2017, v.8(Z1) 127-130

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探索、机遇与希望:聚焦2017国际卒中大会重要临床研究
Exploration,Opportunity and Hope:Highlight in International Stroke Conference 2017

彭斌;
PENG Bin;Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;

摘要(Abstract):

2017年国际卒中大会(International Stroke Conference,ISC)于2017年2月22日~24日在美国休斯顿召开,缺血性卒中抗血小板药物的使用成为本次大会关注焦点。本次大会发布了多项重要研究结果:急性缺血性卒中患者中三联强化的抗血小板治疗并未减少卒中复发,同时增加出血风险;替格瑞洛可能在颅内动脉粥样硬化性缺血性卒中的预防中发挥重要作用;西洛他唑减少缺血性卒中复发疗效优于阿司匹林。其他重要研究显示急性卒中后早期(发病后24 h内)与延迟(发病后7 d)使用他汀类药物在改善预后方面并无差异,卒中后24 h内头的位置与预后无显著相关。
International Stroke Conference 2017 was held on Februrary 22-24,2017 in Houston,USA. The use of antiplatelet agents in ischemic stroke has become the highlight of this conference,and results of several studies were presented during the conference. Triple antiplatelet therapy was not superior to guideline-recommended treatment in preventing recurrent strokes in patients who suffered a recent ischemic stroke or transient ischemic attack( TIA). Ticagrelor showed stronger efficacy than aspirin in the prevention of recurrent acute stroke or TIA especifically related to ipsilateral atherosclerotic stenosis. The antiplatelet agent cilostazol was noninferior to aspirin in preventing vascular events in patients with a recent ischemic stroke and a history of intracerebral hemorrhage(ICH) or multiple microbleeds. Patients with mild acute ischemic stroke did not derive more benefit from initiating statins in the first 24 hours after stroke than a week after the event in a randomized controlled study. There was no significant correlation between head position and prognosis in the first 24 hours after stroke.

关键词(KeyWords): 抗血小板药物;卒中预防;疗效
antiplatelet agent;stroke prevention;efficacy

Abstract:

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基金项目(Foundation): 国家高技术研究发展计划(863计划)

作者(Author): 彭斌;
PENG Bin;Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;

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