协和医学杂志

2020, v.11(01) 85-90

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长链非编码RNA在骨关节炎发生发展中的作用
Roles of Long Noncoding RNAs in the Development and Progression of Osteoarthritis

于辰曦;孙水;
YU Chen-xi;SUN Shui;Department of Joint Surgery,Provincial Hospital Affiliated to Shandong University;

摘要(Abstract):

骨关节炎(osteoarthritis,OA)是一种老年人中最为常见的慢性关节疾病,其主要特征表现为关节软骨退行性变,但确切发病机制尚不十分明确。长链非编码RNA (long non-coding RNAs,lncRNAs)是一种长度超过200个核苷酸的RNA,缺少开放阅读框和蛋白编码功能。近年来研究发现,lncRNAs在正常关节软骨与OA关节软骨中的表达呈现差异化,且部分差异化表达的lncRNAs通过调控细胞凋亡、软骨细胞外基质降解、炎症反应、血管生成、细胞自噬、软骨细胞应力响应等过程参与了OA的发生发展。本文将对lncRNAs在OA发生发展中的作用进行综述,以期为OA的诊断和特异性治疗提供新靶点。
Osteoarthritis( OA),the most common chronic joint disease in the elderly population,is mainly characterized by the degeneration of articular cartilage and its pathogenesis is not fully understood yet.Long non-coding RNAs( lncRNAs) are of a new class of regulatory non-coding RNAs with a length longer than 200 nucleotides. They lack open reading frames and have no potential capacity forprotein translation. Increasing evidence indicates that LncRNAs can be differentially expressed in the normal articular cartilage and OA cartilage. Moreover,some lncRNAs have been shown to be involved in multiple pathological processes of OA,including extracellular matrix degradation,inflammatory responses,apoptosis,angiogenesis,autophagy,the response of chondrocytes to mechanic stress,etc. In this review article,we will focus on the function of lncRNAs in the development and progression of OA and the potential new targets that might be used for the diagnosis and treatment of OA.

关键词(KeyWords): 长链非编码RNA;骨关节炎;关节软骨;软骨细胞
long non-coding RNAs;osteoarthritis;articular cartilage;chondrocyte

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作者(Author): 于辰曦;孙水;
YU Chen-xi;SUN Shui;Department of Joint Surgery,Provincial Hospital Affiliated to Shandong University;

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