协和医学杂志

2017, v.8(Z2) 229-234

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抗缪勒管激素的临床应用
Clinical Application of Anti-Müllerian Hormone

邱玲;李丹丹;程歆琦;
QIU Ling;LI Dan-dan;CHENG Xin-qi;Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;

摘要(Abstract):

抗缪勒管激素(anti-Müllerian hormone,AMH)是由女性卵泡颗粒细胞和男性睾丸支持细胞分泌的二聚体糖蛋白,可抑制女性卵泡的募集和生长,调节男性睾丸间质细胞的功能。目前文章多阐述其临床应用:检测血清AMH的水平可用于评估卵巢储备,预测辅助生殖过程中的卵巢反应,评估肿瘤患者卵巢储备,辅助诊断多囊卵巢综合征、卵巢早衰及预测绝经等,但对其检测方法和参考区间研究阐述较少。近年来,随着AMH检测技术的发展,临床应用领域越来越广泛,本文就AMH的生理、临床应用、检测方法和参考区间等问题进行深入探讨。
Anti-Müllerian hormone( AMH) is a dimeric glycoprotein secreted by follicular granulosa cell and sertoli cell. AMH inhibits the recruitment and growth of follicles in female,and adjusts the function of leydig cells in male. Serum AMH level is a potential marker for ovarian reserve. At present,the article elaborated its clinical application: the level of serum AMH can be used to evaluate ovarian reserve,to predict ovarian response during assisted reproductive process,to evaluate ovarian reserve of cancer patients,to diagnose polycystic ovary syndrome,premature ovarian failure and predictive menopause. There are few studies on the detection methods and reference intervals. With the development of detection technology,AMH has become more widely used in clinical medicine.The physiology,clinical application,assay methods and reference intervals of AMH are discussed in this article.

关键词(KeyWords): 抗缪勒管激素;卵巢储备;卵巢早衰;多囊卵巢综合征
anti-Müllerian hormone;ovarian reserve;premature ovarian failure;polycystic ovary syndrome

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作者(Author): 邱玲;李丹丹;程歆琦;
QIU Ling;LI Dan-dan;CHENG Xin-qi;Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences &Peking Union Medical College;

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