协和医学杂志

2017, v.8(Z1) 117-121

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精准医疗时代的病理学发展
Development of Pathology in Coming Era of Precision Medicine

张波;
ZHANG Bo;Department of Pathology,Health Science of Peking University,Peking University Third Hospital;

摘要(Abstract):

精准医学的发展已成为当今世界医疗领域的主题。在新兴生物与信息技术的推动下,病理学正在经历学科重新布局和改造:即从器官、组织、细胞到亚细胞器以及分子复合体的各层次整合,且与放射、磁共振成像、超声等影像学结合进而诞生形态组学,同时与基因组等分子组学建立关联性,实现形态与功能的确实联系;并与环境、社会及人文因素整合,实现基于医疗大数据的分子病理流行病学。这些发展将重新定义病理学在精准医学时代中的桥梁作用。
The development of precision medicine has been the focus of medical field in the world. With the promotion of emerging biotechnology and information technology,pathology is experiencing subject redistribution and reconstruction. With the integratation of organ,tissue,cell,subcellular organelle and molecular complex,and with the combination of radiology,magnetic resonance and ultrasonic imaging,morphomics is established. At the same time,morphomics has established relevance with genomics and other molecular biology to establish connection between morphology and function,and has integrated with environmental,social and human factors to achieve molecular pathologic epidemiology based on large medical data analysis. It is believed that these developments will redefine the bridge role of the pathology in the coming era of precision medicine.

关键词(KeyWords): 精准医学;病理学;形态组学;分子病理流行病学
precision medicine;pathology;morphomics;molecular pathologic epidemiology

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作者(Author): 张波;
ZHANG Bo;Department of Pathology,Health Science of Peking University,Peking University Third Hospital;

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