金旗;罗勤;赵智慧;柳志红;
JIN Qi;LUO Qin;ZHAO Zhi-hui;LIU Zhi-hong;Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences & Peking Union Medical College;

• 1:中国医学科学院北京协和医学院国家心血管病中心阜外医院肺血管病中心

摘要(Abstract)：

微小RNA-21(microRNA-21,miRNA-21)是一种小的内源性非编码RNA,可广泛表达于多种组织,在多种疾病的发生和发展中发挥重要作用。近年来,miRNA-21在肺动脉高压中的作用受到广泛关注,而其在各亚型中的角色不尽相同甚至相互矛盾。本文综述近年来miRNA-21在肺动脉高压中的研究进展,从miRNA-21参与的病理生理过程、miRNA-21在各种类型肺动脉高压中的作用、当前研究的不足等方面加以综述,以期明确miRNA-21在肺动脉高压发病机制中的作用,为未来研究提供参考。
MicroRNA-21(miRNA-21), a kind of small endogenous non-coding RNA, is widely expressed in various tissues and plays a pivotal role in the occurrence and development of many diseases. In recent years, the role of miRNA-21 in pulmonary hypertension(PH) has attracted extensive attention, and its function in subtypes of PH is not always the same or even contradictory. This review summarized recent advances of miRNA-21 in PH, encompassing pathophysiological processes mediated by miRNA-21, its roles in subtypes of PH, and insufficiency of current researches, in order to figure out the role of miRNA-21 in PH and provide a reference for future studies.

关键词(KeyWords)： 微小RNA-21;肺动脉高压;病理生理学
microRNA-21;pulmonary hypertension;pathophysiology

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81641005)

作者(Author): 金旗;罗勤;赵智慧;柳志红;
JIN Qi;LUO Qin;ZHAO Zhi-hui;LIU Zhi-hong;Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences & Peking Union Medical College;

Email:

DOI:

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