协和医学杂志

2020, v.11(04) 430-438

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微小RNA-21在肺动脉高压发病机制中的研究进展
MicroRNA-21 in the Pathogenesis of Pulmonary Hypertension

金旗;罗勤;赵智慧;柳志红;
JIN Qi;LUO Qin;ZHAO Zhi-hui;LIU Zhi-hong;Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

微小RNA-21(microRNA-21,miRNA-21)是一种小的内源性非编码RNA,可广泛表达于多种组织,在多种疾病的发生和发展中发挥重要作用。近年来,miRNA-21在肺动脉高压中的作用受到广泛关注,而其在各亚型中的角色不尽相同甚至相互矛盾。本文综述近年来miRNA-21在肺动脉高压中的研究进展,从miRNA-21参与的病理生理过程、miRNA-21在各种类型肺动脉高压中的作用、当前研究的不足等方面加以综述,以期明确miRNA-21在肺动脉高压发病机制中的作用,为未来研究提供参考。
MicroRNA-21(miRNA-21), a kind of small endogenous non-coding RNA, is widely expressed in various tissues and plays a pivotal role in the occurrence and development of many diseases. In recent years, the role of miRNA-21 in pulmonary hypertension(PH) has attracted extensive attention, and its function in subtypes of PH is not always the same or even contradictory. This review summarized recent advances of miRNA-21 in PH, encompassing pathophysiological processes mediated by miRNA-21, its roles in subtypes of PH, and insufficiency of current researches, in order to figure out the role of miRNA-21 in PH and provide a reference for future studies.

关键词(KeyWords): 微小RNA-21;肺动脉高压;病理生理学
microRNA-21;pulmonary hypertension;pathophysiology

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基金项目(Foundation): 国家自然科学基金(81641005)

作者(Author): 金旗;罗勤;赵智慧;柳志红;
JIN Qi;LUO Qin;ZHAO Zhi-hui;LIU Zhi-hong;Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences & Peking Union Medical College;

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