协和医学杂志

2013, v.4(02) 113-117

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频域光学相干断层扫描观察特发性黄斑裂孔患者脉络膜厚度
Spectral-domain Optical Coherence Tomography Findings of Choroidal Thickness in Eyes of Patients with Idiopathic Macular Holes

陈迪;李略;杨治坤;董方田;
CHEN Di,LI Lue,YANG Zhi-kun,DONG Fang-tian Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

摘要(Abstract):

目的研究特发性黄斑裂孔(idiopathic macular holes,IMH)患眼及对侧眼的脉络膜厚度。方法研究共纳入20例单眼IMH患者及20名性别和年龄相匹配的正常对照者。采用频域光学相干断层扫描深度增强成像技术测量IMH患者患眼、对侧健眼及正常对照眼中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT)及中心凹鼻侧、颞侧、上方和下方各相距1和2mm处共9个位点的脉络膜厚度。结果 IMH患眼组、对侧健眼组及正常对照组的SFCT均值分别为(161.53±50.50)、(204.95±59.58)、(248.00±63.40)μm(P=0.000)。方差分析显示3组间所有位点的脉络膜厚度均值差异均有统计学意义(P<0.05)。Tukey-Kramer检验多重比较发现IMH患眼组各个位点的脉络膜厚度均值较正常对照组显著降低(P<0.01),对侧健眼组在除中心凹上方2mm及下方2mm处的脉络膜厚度值以外的7个位点较正常对照组均显著降低(P<0.05)。结论 IMH患者患眼的脉络膜厚度明显变薄,对侧健眼的脉络膜厚度亦有不同程度变薄,提示IMH的发生与脉络膜的血流灌注状态可能存在一定关系。
Objective To determine the choroidal thickness in the eyes with idiopathic macular hole (IMH) and the unaffected fellow eyes. Methods Twenty IMH patients and 20 age-and sex-matched healthy controls were recruited. Enhanced depth images were obtained using spectal-domain optical coherence tomography. The choroidal thickness was measured in the subfoveal area and 1 mm and 2 mm away from the fovea in the nasal,temporal,superior and inferior regions. Results The mean subfoveal area choroidal thickness was (161. 53 ± 50. 50) μm in the eyes with IMH,(204. 95 ± 59. 58) μm in the fellow eyes,and (248. 00 ± 63. 40) μm in the control group (P = 0. 000) . The choroidal thickness at all measured regions showed significant differences among three groups (P < 0. 05) . Compared with the control group,the choroidal thickness was significantly thinner in eyes with IMH (P < 0. 01) and unaffected fellow eyes except for the superior choroidal thickness at 2 mm and inferior choroidal thickness at 2 mm (P < 0. 05) . Conclusion Choroidal thickness decreases in eyes with IMH and may also reduce in the unaffected fellow eyes,suggesting that the development of IMH may be associated with the choroid perfusion.

关键词(KeyWords): 特发性黄斑裂孔;频域光学相干断层扫描;脉络膜厚度
idiopathic macular hole; spectral-domain optical coherence tomography; choroidal thickness

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作者(Author): 陈迪;李略;杨治坤;董方田;
CHEN Di,LI Lue,YANG Zhi-kun,DONG Fang-tian Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

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