协和医学杂志

2022, v.13(06) 936-941

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肠道微生态与血流动力学
Gut Microbiota in Hemodynamics

潘晓俊;陈德昌;
PAN Xiaojun;CHEN Dechang;Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine;

摘要(Abstract):

肠道微生态是由原核微生物(细菌)、真核微生物(包括真菌以及原生动物)和病毒构成的强大“器官”,在机体营养代谢、维持肠道黏膜上皮屏障的完整性、免疫调节中发挥至关重要的作用。已有研究表明,肠道微生态与多种疾病的发病机制相关,如神经精神性疾病、自身免疫性疾病、癌症以及慢性代谢性疾病等。近年来的研究发现,肠道微生态能够通过氧化三甲胺和短链脂肪酸及其受体途径对血流动力学发挥调控作用;同时,肠道微生态失调、易位激活机体炎症反应可影响机体血流动力学的稳定。本文梳理二者之间的关系,以期为进一步开展相关研究提供借鉴。
The gut microbiota is a powerful “organ” composed of prokaryotic organisms(bacteria), eukaryotic microorganisms(including fungi and protozoa) and viruses, which plays a crucial role in the nutrition metabolism, maintenance of the integrity of intestinal mucosal barrier, and immune regulation of the body. Researches have shown that intestinal microecology is related to the pathogenesis of many diseases, such as neuropsychiatric diseases, autoimmune diseases, cancer and chronic metabolic diseases. Recent studies have found that gut microbiota can regulate hemodynamics through the oxidation of trimethylamine and short chain fatty acids. At the same time, gut microbiota disorder and translocation can activate the body's inflammatory response, affecting the stability of the body's hemodynamics.In this article, we summarize the relationship between gut microbiota and hemodymamics, in order to provide reference for further research.

关键词(KeyWords): 肠道微生态;血流动力学;重症
gut microbiota;hemodynamics;critical care

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81873944,82172152);; 上海市科学技术委员会(20DZ2200500)~~

作者(Authors): 潘晓俊;陈德昌;
PAN Xiaojun;CHEN Dechang;Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine;

参考文献(References):

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