协和医学杂志

2019, v.10(03) 211-215

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粪菌移植治疗炎症性肠病的争议
Controversy of Fecal Microbiota Transplantation in Treating Patients with Inflammatory Bowel Disease

张发明;李玥;
ZHANG Fa-ming;LI Yue;Medical Center for Digestive Diseases,the Second Affiliated Hospital,Nanjing Medical University;Department of Microbiotherapy,the Sir Run Run Hospital,Nanjing Medical University;Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

已有报道表明粪菌移植治疗炎症性肠病前景可观,且针对溃疡性结肠炎的临床随机对照研究支持粪菌移植的有效性。但涉及粪菌制备的方法学、移植途径、供体筛选、患者选择以及诱发病情活动的潜在风险等方面尚存诸多未知,因此,粪菌移植目前仅适合在临床试验等特定条件下用于炎症性肠病治疗。
Fecal microbiota transplantation( FMT) is reported to be a promising therapy for patients with inflammatory bowel disease( IBD). Randomized controlled trials have reported the effectiveness of FMT in the treatment of ulcerative colitis. However,many associated unknowns still remain,such as the preparation,the transplantation route,donor and recipient selection,and potential adverse events including the risk of IBD flare post-FMT. Therefore,FMT should only be administered in patients with IBD in a circumstanced setting,such as clinical trials.

关键词(KeyWords): 粪菌移植;溃疡性结肠炎;克罗恩病;不良事件
fecal microbiota transplantation;ulcerative colitis;Crohn's disease;adverse events

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基金项目(Foundation): 中国医学科学院医学与健康科技创新工程协同创新团队“人体微生物组平台建设与应用研究”(2017-I2M-3-017);; 江苏省重大研发计划(BE2018751)

作者(Author): 张发明;李玥;
ZHANG Fa-ming;LI Yue;Medical Center for Digestive Diseases,the Second Affiliated Hospital,Nanjing Medical University;Department of Microbiotherapy,the Sir Run Run Hospital,Nanjing Medical University;Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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