王亮;吕珂;陈丽萌;夏鹏;姜玉新;戴晴;
WANG Liang;L Ke;CHEN Li-meng;XIA Peng;JIANG Yu-xin;DAI Qing;Department of Ultrasound,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Nephrology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

• 1:中国医学科学院北京协和医学院北京协和医院超声医学科
• 2:中国医学科学院北京协和医学院北京协和医院肾内科

摘要(Abstract)：

目的评价声触诊组织定量(virtual touch tissue quantification,VTQ)技术在IgA肾病(IgA nephropathy,IgAN)的应用价值。方法选择2012年1月1日至4月30日北京协和医院经肾活检证实的28例IgAN患者,对所有患者左肾进行常规超声(肾脏长径、皮质厚度、叶间动脉阻力指数)及VTQ超声[剪切波速度(shear wave velocity,SWV)]检查。分析常规超声与VTQ指标间,以及各超声指标与患者临床/病理指标-慢性肾脏病(chronic kidney disease,CKD)分期、Lee分级、肾小球硬化指数(glomerular sclerosis index,GSI)、肾小管萎缩(tubular atrophy,TA)以及肾间质纤维化(interstitial fibrosis,IF)的相关性。结果 IgAN患者肾脏常规超声指标与其VTQ结果、临床/病理指标无显著相关性(P>0.05);VTQ测定的SWV与CKD分期(r=-0.382,P=0.045)、Lee分级(r=-0.407,P=0.031)及IF(r=-0.397,P=0.036)呈负相关,与GSI和TA无显著相关性(P>0.05)。结论通过VTQ技术测定的肾皮质SWV与多项临床/病理指标存在相关性,这一新型超声弹性成像技术的临床意义值得进一步研究。
Objective To evaluate the application of virtual touch tissue quantification( VTQ) technique in immunoglobulin A nephropathy( IgAN).Methods A total of 28 patients were included in present study who underwent kidney biopsy in Peking Union Medical College Hospital from January 1,2012 to April 30,2012.On sonography,conventional [length( L),thickness( T),resistive index( RI) ],and VTQ( shear wave velocity,SWV) parameters of left kidney were measured.Then using Spearman correlation analysis,the correlations between SWV and clinicopathologic parameters [chronic kidney disease( CKD) stage,Lee grade,glomerular sclerosis index( GSI),tubular atrophy( TA),interstitial fibrosis( IF) ] and the association of SWV and conventional ultrasound measurements were evaluated.Results No significant correlation was found between conventional ultrasound measurements and SWV,as well as clinicopathologic parameters( all P > 0.05).However,Spearman analysis indicated that SWV showed significant correlations with CKD stage( r =-0.382,P = 0.045),Lee grade( r =-0.407,P = 0.031),and IF( r =-0.397,P = 0.036).Conclusions As a novel sono-elastography technique,VTQ correlates with multiple clinicopathologic parameters by measuring renal cortical stiffness.Therefore it is of great value in clinical application and warrants further investigation.

关键词(KeyWords)： 声触诊组织定量技术;IgA肾病;弹性成像;病理
virtual touch tissue quantification;immunoglobulin A nephropathy;elastography;pathology

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 王亮;吕珂;陈丽萌;夏鹏;姜玉新;戴晴;
WANG Liang;L Ke;CHEN Li-meng;XIA Peng;JIANG Yu-xin;DAI Qing;Department of Ultrasound,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Nephrology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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