协和医学杂志

2020, v.11(04) 370-376

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靶向生长抑素受体的神经内分泌肿瘤核素诊断与治疗
Radionuclide Imaging and Therapy of Neuroendocrine Neoplasm by Targeting the Somatostatin Receptor

刘清杏;臧洁;任家坤;朱朝晖;
LIU Qing-xing;ZANG Jie;REN Jia-kun;ZHU Zhao-hui;Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

摘要(Abstract):

神经内分泌肿瘤(neuroendocrine neoplasm, NEN)是以神经内分泌分化为主要特征的一组不同类型的肿瘤。多数NEN细胞表面有生长抑素受体(somatostatin receptor, SSTR)高表达,为核医学分子影像诊断及多肽-受体介导的放射性核素治疗(peptide receptor radionuclide therapy, PRRT)提供了重要靶点。这一方向近年来已成为国内外的研究热点,且临床转化和应用进展迅速,不断出现新的突破。本文系统介绍靶向SSTR的核医学分子影像和PRRT治疗的现状与进展,以及在NEN诊疗中的主要优势和重要价值,为相关专业临床诊疗决策提供参考。
Neuroendocrine neoplasm(NEN) is a heterogeneous group of tumors characterized by neuroendocrine differentiation. Most of the tumor cells show high-level expression of the somatostatin receptor(SSTR), which provides an important target for molecular imaging and peptide receptor radionuclide therapy(PRRT). This area has become a research hotspot at home and abroad in recent years. In addition, rapid progress and new breakthroughs have been made in clinical translation and application continuously. This article reviewed the new advances in SSTR-targeted nuclear molecular imaging and PRRT, and summarized their main advantages and important values in the diagnosis and treatment of NEN, in hope of giving relevant professional doctors a reference for clinical diagnosis and treatment.

关键词(KeyWords): 神经内分泌肿瘤;核医学;分子影像;多肽-受体介导的放射性核素治疗
neuroendocrine neoplasm;nuclear medicine;molecular imaging;peptide receptor radionuclide therapy

Abstract:

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基金项目(Foundation): 国家自然科学基金(8187071730);; 中国医学科学院重大协同创新项目(2019-I2M-1-001);中国医学科学院临床与转化医学研究基金(2019XK320032)

作者(Author): 刘清杏;臧洁;任家坤;朱朝晖;
LIU Qing-xing;ZANG Jie;REN Jia-kun;ZHU Zhao-hui;Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

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