协和医学杂志

2011, v.2(03) 209-212

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高分辨磁共振成像用于阿尔茨海默病嗅球体积测量
Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

有慧;牛富生;王剑;郑福玲;孟春玲;张振馨;倪道凤;冯逢;
YOU Hui1, NIU Fu-sheng2, WANG Jian3, ZHENG Fu-ling1, MENG Chun-ling1, ZHANG Zhen-xin2, NI Dao-feng3, FENG Feng1 1Department of Radiology, 2Department of Neurology, 3Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

摘要(Abstract):

目的评价阿尔茨海默病(Alzheimer disease,AD)患者嗅球体积变化。方法对14例AD患者及25名正常老年志愿者行高分辨嗅球磁共振成像(magnetic resonance imaging,MRI),测量嗅球体积。结果 AD患者较大侧嗅球体积为(32·2±7·7)mm3,小于正常老年志愿者的(40·6±6·6)mm3(P=0·002)。AD患者嗅球体积与简易精神状态检查量表(mini-mental state examination,MMSE)评分无明显相关性(P=0·205)。结论 AD患者嗅球体积减小,符合神经病理学表现。MRI可以发现AD患者嗅球体积改变,可能为AD诊断提供帮助。
Objective To explore the change of olfactory bulb (OB) volume in patients with Alzheimer disease (AD) and assess the value of high-resolution magnetic resonance imaging (MRI) in measuring OB volume. Methods Fourteen AD patients and 25 normal aging volunteers (control group) underwent high-resolution MRI imaging of OB and the OB volume was measured. Results The OB volume in AD patients [ (32.2±7.7) mm3] was significantly smaller than that in control group [(40.6±6.6) mm3] (P=0.002). The OB volume in AD patients didn't correlate significantly with their mini-mental state examination (MMSE) scores (P=0.205). Conclusions AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.

关键词(KeyWords): 阿尔茨海默病;磁共振成像;嗅球
Alzheimer disease; magnetic resonance imaging; olfactory bulb

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作者(Author): 有慧;牛富生;王剑;郑福玲;孟春玲;张振馨;倪道凤;冯逢;
YOU Hui1, NIU Fu-sheng2, WANG Jian3, ZHENG Fu-ling1, MENG Chun-ling1, ZHANG Zhen-xin2, NI Dao-feng3, FENG Feng1 1Department of Radiology, 2Department of Neurology, 3Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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