协和医学杂志

2022, v.13(05) 725-731

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肠道菌群与心血管健康:心肠密不可分
Gut Microbiome and Cardiovascular Health: Heart and Gut are Inextricably Linked

赵心悦;胡晓敏;张抒扬;
ZHAO Xinyue;HU Xiaomin;ZHANG Shuyang;Department of Cardiology,Chinese Academy of Medical Sciences & Peking Union Medical College;State Key Laboratory of Complex Severe and Rare Disease,Chinese Academy of Medical Sciences & Peking Union Medical College;Medical Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

近年来,随着多组学和下一代测序技术的发展,肠道菌群与人类心血管疾病的关系受到广泛关注。肠道菌群作为“微生物器官”,通过脂多糖等细胞成分、氧化三甲胺、短链脂肪酸等代谢物直接调节机体健康状态,也可通过细菌及其产物影响机体免疫。“肠-心轴”有望成为心血管疾病防治的新突破口。本文就肠道菌群与心血管疾病的关系、影响心血管健康的可能途径以及多种因素对肠道菌群的调控进行阐述。
In recent years, with the progress of multi-omics and next-generation sequencing technology, the association between gut microbiome and cardiovascular diseases has attracted great attention around the world. Gut microbiota, as a “microbial organ”,directly regulates the host's health status through lipopolysaccharide, metabolites like trimethylamine oxide and short-chain fatty acids, and affects the host's immunity through bacteria and their products. “Gut-heart axis” may be a breakthrough in the prevention and treatment of cardiovascular diseases. The paper briefly discusses the relationship between gut microbiome and cardiovascular diseases, the possible ways in which gut microbes affect cardiovascular health, and the regulation of gut microbiota by various factors.

关键词(KeyWords): 肠道菌群;心血管疾病;代谢物;免疫
gut microbiome;cardiovascular disease;metabolites;immunity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(8217022134);; 北京市自然科学基金(7202152);; 北京协和医院中央高水平医院临床科研专项青年培优计划基金(2022-PUMCH-A-026)~~

作者(Authors): 赵心悦;胡晓敏;张抒扬;
ZHAO Xinyue;HU Xiaomin;ZHANG Shuyang;Department of Cardiology,Chinese Academy of Medical Sciences & Peking Union Medical College;State Key Laboratory of Complex Severe and Rare Disease,Chinese Academy of Medical Sciences & Peking Union Medical College;Medical Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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