李超;李航;
LI Chao;LI Hang;Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College;

• 1:中国医学科学院北京协和医学院北京协和医院肾内科

摘要(Abstract)：

虚拟切片技术能够将传统的病理切片转换为数字图像,使其具备长期保存、容易获取等特点,正逐渐替代玻璃切片和光学显微镜用于病理远程会诊、科研和教学,但其在肾内科领域的应用尚未广泛开展。本文通过文献复习和实践经验,对虚拟切片技术在肾内科临床、科研和教学中的应用前景进行阐述,一方面强调其潜在价值,另一方面对目前实际应用中存在的问题及挑战提出解决建议。
Virtual slide technology can transform traditional pathological slices into digital images, which is gradually replacing glass slices and optical microscopes in remote consultation, scientific research, and teaching of pathology because digital images can be preserved longer and easier to obtain. However, its application in the field of nephrology has not been widely carried out. Through literature review and practical experience, this paper expounds the prospect of application of virtual slide technology in clinical practice, scientific research, and teaching of nephrology, emphasizing its potential value on the one hand, and putting forward some suggestions to solve the problems and challenges in the current practical application on the other hand.

关键词(KeyWords)： 虚拟切片技术;数字病理;肾脏病学
virtual slide technology;digital pathology;nephrology

Abstract:

Keywords:

基金项目(Foundation): 北京协和医学院小规模特色办学经费资助青年教师培养项目(2015zlgc0710)

作者(Author): 李超;李航;
LI Chao;LI Hang;Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College;

Email:

DOI:

参考文献(References)：

• [1] Weinstein RS.Prospects for telepathology[J].Hum Pathol,1986,17:433- 434.
• [2] Farris AB,Cohen C,Rogers TE,et al.Whole Slide Imaging for Analytical Anatomic Pathology and Telepathology:Practical Applications Today,Promises,and Perils[J].Arch Pathol Lab Med,2017,141:542- 550.
• [3] Jones NC,Nazarian RM,Duncan LM,et al.Interin-stitutional whole slide imaging teleconsultation service development:assessment using internal training and clinical consultation cases[J].Arch Pathol Lab Med,2015,139:627- 635.
• [4] Gandomkar Z,Brennan PC,Mello-Thoms C.Computer-based image analysis in breast pathology[J].J Pathol Inform,2016,7:43.
• [5] Helin HO,Tuominen VJ,Ylinen O,et al.Free digital image analysis software helps to resolve equivocal scores in HER2 immunohistochemistry[J].Virchows Arch,2016,468:191- 198.
• [6] Morioka T,Niikura N,Kumaki N,et al.Comparison of Ki- 67 labeling index measurements using digital image analysis and scoring by pathologists[J].Breast Cancer,2018,25:768- 777
• [7] Klauschen F,Wienert S,Schmitt WD,et al.Standardized Ki67 Diagnostics Using Automated Scoring—Clinical Validation in the GeparTrio Breast Cancer Study[J].Clin Cancer Res,2015,21:3651- 3657.
• [8] Jansen I,Lucas M,Savci-Heijink CD,et al.Histopa-thology:ditch the slides,because digital and 3D are on show[J].World J Urol,2018,36:549- 555.
• [9] Jen KY,Olson JL,Brodsky S,et al.Reliability of whole slide images as a diagnostic modality for renal allograft biopsies[J].Hum Pathol,2013,44:888- 894.
• [10] Yin F,Han G,Bui MM,et al.Educational Value of Digital Whole Slides Accompanying Published Online Pathology Journal Articles:A Multi-Institutional Study[J].Arch Pathol Lab Med,2016,140:694- 697.
• [11] Li L,Dangott BJ,Parwani AV.Development and use of a genitourinary pathology digital teaching set for trainee education[J].J Pathol Inform,2010,1:2- 5.
• [12] Kumar RK,Velan GM,Korell SO,et al.Virtual microscopy for learning and assessment in pathology[J].J Pathol,2004,204:613- 618.
• [13] Marsch AF,Espiritu B,Groth J,et al.The effectiveness of annotated (vs.non-annotated) digital pathology slides as a teaching tool during dermatology and pathology residencies[J].J Cutan Pathol,2014,41:513- 518.
• [14] Van Den Tweel JG,Bosman FT.The use of virtual slides in the EUROPALS examination[J].Diagn Pathol,2011,6 Suppl 1:S23-S26.
• [15] Walkowski S,Lundin M,Szymas J,et al.Students' performance during practical examination on whole slide images using view path tracking[J].Diagn Pathol,2014,9:208- 215.
• [16] Krupinski EA,Tillack AA,Richter L,et al.Eye-movement study and human performance using telepathology virtual slides:implications for medical education and differences with experience[J].Hum Pathol,2006,37:1543- 1556.
• [17] Crowley RS,Legowski E,Medvedeva O,et al.Evaluation of an intelligent tutoring system in pathology:effects of external representation on performance gains,metacognition,and acceptance[J].J Am Med Inform Assoc,2007,14:182- 190.
• [18] Horn AJ,Czarnecki D,Lele SM.Interactive case vignettes utilizing simulated pathologist-clinician encounters with whole slide imaging and video tutorials of whole slide scans improves student understanding of disease processes[J].J Pathol Inform,2012,3:34-38.