协和医学杂志

2017, v.8(Z2) 300-304

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PTEN基因与消化系统器官纤维化
PTEN and Digestive Organ Fibrosis

张晓云;郝建宇;
ZHANG Xiao-yun;HAO Jian-yu;Department of Gastroenterology,Beijing Chaoyang Hospital Affiliated to Capital Medical University;

摘要(Abstract):

PTEN基因是目前发现的重要抑癌基因之一,其蛋白产物具有独特的蛋白磷酸酶及脂质磷酸酶双重活性。PTEN蛋白分布广泛、生物学功能复杂、调节方式多样,可通过多种信号转导途径对细胞的形态、增殖、分化、黏附、迁移等发挥调节作用。随着对PTEN基因的深入研究,揭示该基因与多种消化器官纤维化过程密切相关,并可能成为逆转及治疗纤维化的潜在靶点。
PTEN gene is one of the most important tumor suppressor gene,which acts through a unique protein phosphatase and lipid phosphates activity. PTEN protein has a wide distribution,complex biological function,and a variety of regulation modes,which can regulate the cell morphology,proliferation,differentiation,adhesion and migration through a variety of signaling pathways. With the further study of PTEN,it is found that the gene is closely related to the digestive process of many kinds of digestive organs,and may be a potential target for the reversing and treatment of fibrosis.

关键词(KeyWords): PTEN;消化系统疾病;纤维化;细胞外基质
PTEN;digestive disease;fibrosis;extracellular matrix

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81470888)

作者(Author): 张晓云;郝建宇;
ZHANG Xiao-yun;HAO Jian-yu;Department of Gastroenterology,Beijing Chaoyang Hospital Affiliated to Capital Medical University;

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