协和医学杂志

2020, v.11(05) 606-614

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单细胞测序及其与未来脑恶性肿瘤的诊疗
Single-cell Sequencing and Its Prospect in the Management of Brain Malignant Tumor

王月坤;刘芃昊;王裕;马文斌;
WANG Yue-kun;LIU Peng-hao;WANG Yu;MA Wen-bin;Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

摘要(Abstract):

单细胞测序技术可对分散的单个细胞分别进行基因组、转录组、表观遗传组或多组学测序,可从较少的肿瘤细胞中获得取可能多的信息。相较于整体测序,对单细胞测序技术在肿瘤内和肿瘤间异质性的研究有助于了解肿瘤动态变化机制。利用单细胞测序技术研究脑恶性肿瘤进展过程中不同阶段的分子标志物、特殊信号通路、基因表达及免疫应答等,为脑恶性肿瘤的评估、诊断、分型和治疗提供了新的思路。本文将对单细胞测序及其与未来脑恶性肿瘤的诊疗进展进行综述。
Single-cell sequencing is characterized by precise analysis of genome, transcriptome, epigenomics, and multi-omics of cancer cells at the single-cell level, which promotes understanding of evolution and dynamic changes in cancer niches. Yet, intra-and extra-tumor heterogeneity of brain tumors can make it difficult to obtain a full-view landscape in bulky tumor assessment. Based on single-cell sequencing, genomic instability, biomarker, signaling pathway and immune responses in the tumor environment of a brain malignant tumor can be uncovered, which provides a novel opportunity for assessment, diagnosis, classification and management of brain malignant tumors. In this article, we review the progress of single-cell sequencing and the prospect in the management of brain malignant tumor in the future.

关键词(KeyWords): 单细胞测序;恶性肿瘤;胶质瘤;脑转移瘤;精准医疗
single-cell sequencing;malignant tumor;glioma;brain metastases;precision medicine

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基金项目(Foundation): 中国医学科学院医学与健康科技创新工程(2016-I2M-2-001)

作者(Author): 王月坤;刘芃昊;王裕;马文斌;
WANG Yue-kun;LIU Peng-hao;WANG Yu;MA Wen-bin;Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

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