协和医学杂志

2020, v.11(04) 439-442

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子宫内膜异位症相关疼痛机制研究进展
Advances in the Mechanisms of Pain Associated with Endometriosis

苏文良;马璐璐;张秀华;黄宇光;
SU Wen-liang;MA Lu-lu;ZHANG Xiu-hua;HUANG Yu-guang;Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

摘要(Abstract):

子宫内膜异位症主要累及育龄期妇女,其发生率约为5%~10%。该疾病的主要表现为疼痛,而目前对于子宫内膜异位症相关疼痛机制的了解较少。现有证据表明,子宫内膜异位病灶及其周围神经及血管异常生成、周围神经敏化、中枢神经系统形态和功能改变均与子宫内膜异位症相关疼痛有关。本文着重探讨子宫内膜异位症相关疼痛外周和中枢神经系统可能的发病机制,以期为临床诊疗提供理论依据。
Pain is the main symptom of endometriosis, and about 5% to 10% of reproductive-aged women become potential patients in pain. However, to date, the mechanisms of pain associated with endometriosis are still poorly understood. Available evidence shows a lesion surrounded by aberrant nerve fibers and blood vessels, sensitization of the peripheral nerve, morphological and functional anomaly of the central nervous system are all related to pain associated with endometriosis. This review focused on the possible mechanisms of endometriosis-associated pain in the peripheral and central nervous systems,to provide a possible theoretical basis for clinical treatment.

关键词(KeyWords): 子宫内膜异位症;疼痛;中枢神经系统;外周神经系统
endometriosis;pain;central nervous system;peripheral nervous system

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作者(Author): 苏文良;马璐璐;张秀华;黄宇光;
SU Wen-liang;MA Lu-lu;ZHANG Xiu-hua;HUANG Yu-guang;Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

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