协和医学杂志

2017, v.8(Z2) 283-288

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微小RNA在结节性硬化症相关病变中的研究进展
Progress in Research on MicroRNA in Tuberous Sclerosis Complex Related Diseases

郭浩;王文达;蔡燚;张玉石;
GUO Hao;WANG Wen-da;CAI Yi;ZHANG Yu-shi;Department of Urology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

摘要(Abstract):

结节性硬化症(tuberous sclerosis complex,TSC)是一种累及多个器官和系统的常染色体显性遗传疾病,几乎可累及人体所有器官及系统。TSC常表现为皮肤病性损害及内脏良性肿瘤,亦有少部分恶性程度较高的肿瘤,例如室管膜下巨细胞星形细胞瘤(subependymal giant cell astrocytoma,SEGA)、肾细胞癌等。越来越多的证据表明,微小RNA与TSC相关病变的发生有密切关系,起着癌基因或抑癌基因的作用。本文针对微小RNA在TSC相关病变如肺及神经系统疾病中的研究进展作一综述。
Tuberous sclerosis complex( TSC) is an autosomal dominant genetic disease involving multiple organs and systems. It can involve all organs and systems in the body. Nodular sclerosis is often manifested as skin lesions and visceral benign tumors,as well as a small number of highly malignant tumors,such as subependymal giant cell astrocytoma( SEGA),renal cell carcinoma and so on. There is growing evidence that microRNAs( miRNAs) are closely related to TSC related diseases and act as oncogenes or tumor suppressor genes. This paper reviews the progress of study on miRNA in several diseases related to tuberous sclerosis complex.

关键词(KeyWords): 结节性硬化症;微小RNA;分子机制
tuberous sclerosis complex;microRNA;molecular mechanism

Abstract:

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基金项目(Foundation): 国家自然科学基金(81670611);; 北京协和医院中青年科研基金(pumch-2016-2.11)

作者(Author): 郭浩;王文达;蔡燚;张玉石;
GUO Hao;WANG Wen-da;CAI Yi;ZHANG Yu-shi;Department of Urology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;

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