李方塘;杨小利;陈瑞丹;杨永健;
LI Fangtang;YANG Xiaoli;CHEN Ruidan;YANG Yongjian;Department of Cardiology, The General Hospital of Western Theater Command PLA Southwest Jiaotong University;Department of Cardiology, Daping Hospital, Third Military Medical University;

• 1:西南交通大学医学院西部战区总医院心血管内科
• 2:陆军军医大学附属大坪医院心血管内科

摘要(Abstract)：

目的探究身体形态指数(a body shape index, ABSI)与高血压靶器官损伤的关系。方法本研究为横断面调查,研究对象为2020年3月至2021年1月于陆军军医大学附属大坪医院心血管内科住院的高血压患者。采用ASBI三分位数法,将其分为低ASBI组、中ASBI组和高ASBI组。比较3组高血压靶器官损伤检出率差异。采用多因素Logistic回归分析ASBI与高血压靶器官损伤的相关性。结果共入选685例符合纳入和排除标准的高血压患者,其中存在靶器官损伤445例;低ASBI组(ABSI≤0.076)229例、中ASBI组(0.0760.078)228例。高ASBI组左心室肥厚检出率高于低ASBI组(27.63%比12.66%,P<0.001),颈动脉粥样硬化、肾功能损伤检出率高于中ASBI组(39.04%比26.32%,P=0.015;14.04%比5.26%,P=0.007)和低ASBI组(39.04%比25.76%,P=0.008;14.04%比2.62%,P<0.001)。多因素Logistic回归分析结果显示,以低ABSI为参照,高ABSI是高血压患者发生左心室肥厚(OR=2.08,95%CI:1.24～3.50,P<0.001)、肾功能损伤(OR=6.47,95%CI:2.53～16.54,P<0.001)的独立危险因素。结论 ABSI升高与高血压患者肾功能损伤、左心室肥厚具有关联性。
Objective To explore the correlation between a body shape index(ABSI) and target organ injury in patients with hypertension. Methods A cross-sectional study was used to collect related clinical indicators of patients with hypertension who were hospitalized in the Department of Cardiology, Daping Hospital, Third Military Medical University from March 2020 to January 2021. ASBI quantile method was used to divide the patients into low ASBI group, medium ASBI group and high ASBI group. Multiple Logistic regression was used to analyze the correlation between ASBI and target organ injury in patients with hypertension. Results Atotal of 685 patients with hypertensive meeting the inclusion and exclusion criteria were enrolled, of which 445 had target organ damage; 229 cases were in the low ASBI group(ABSI≤0.076), 228 cases were in the medium ASBI group(0.0760.078). The detection rate of left ventricular hypertrophy in the high ASBI group was higher than that in the low ASBI group(27.63% vs. 12.66%,P<0.001). The detection rates of carotid atherosclerosis, and renal function impairment of the high ASBI group were higher than those of the medium ASBI group(39.04% vs. 26.32%,P=0.015;14.04% vs. 5.26%,P=0.007) and low ASBI group(39.04% vs. 25.76%,P=0.008;14.04% vs. 2.62%,P<0.001). The multivariate Logistic regression analysis showed that ABSI was associated with increased left ventricular hypertrophy(OR=2.08,95% CI: 1.24-3.50, P<0.001) and renal injury(OR=6.47,95% CI: 2.53-16.54, P<0.001) in hypertensive patients. ConclusionThe increased ABSI is related to the prevalence of left ventricular hypertrophy and renal damage in hypertensive patients.

关键词(KeyWords)： 身体形态指数;高血压;靶器官损伤;左心室肥厚;肾功能损伤
a body shape index;hypertension;target organ injury;left ventricular hypertrophy;renal damage

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目（81873477）~~

作者(Authors): 李方塘;杨小利;陈瑞丹;杨永健;
LI Fangtang;YANG Xiaoli;CHEN Ruidan;YANG Yongjian;Department of Cardiology, The General Hospital of Western Theater Command PLA Southwest Jiaotong University;Department of Cardiology, Daping Hospital, Third Military Medical University;

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