赵辰阳;朱庆莉;张睿;齐振红;杨萌;姜玉新;
ZHAO Chen-yang;ZHU Qing-li;ZHANG Rui;QI Zhen-hong;YANG Meng;JIANG Yu-xin;Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

• 1:中国医学科学院北京协和医学院北京协和医院超声医学科

摘要(Abstract)：

关节炎性疾病发病率逐年升高,给社会经济造成了巨大负担,其早期诊治具有重要意义。光声成像是一种新型光学影像技术,结合了光显像和超声波接收转换的优点,可对关节开展形态学、微血管及功能成像,并可通过外源性造影剂实现分子成像。近10年来,研究人员开发了一系列光声成像仪器,包括独立光声断层成像系统、多模态影像系统等,针对关节炎性疾病开展了动物实验和人体试验,证实其在关节炎性疾病诊断中的价值,其中配备手持光声探头的一体化双模态光声/超声成像系统易于临床转化,有较好的发展前景。
This decade has witnessed a growing prevalence of chronic arthritis all around the world. Early diagnosis of arthritis can be essential for timely treatment and a better prognosis. Photoacoustic imaging(PAI), a multi-functional imaging technique, has been applied for visualizing morphological structures of peripheral joints and small vessels in small joints. Blood oxygenation and other perfusion indexes can also be calculated by PAI, allowing functional evaluation of joint tissues. The exogenous photoacoustic contrast agent that is targeted at some specific molecular biomarkers enables molecular imaging with the use of photoacoustic modalities. Several photoacoustic computed tomography(PACT) modalities have been developed for joint imaging, including some dual-modality systems, which integrate a photoacoustic system with other imaging methods. Taking advantage of the stability and maturity of commercial US units, the co-registration of photoacoustic and ultrasound(PA/US) systems with a portable probe can be an essential step for future clinical translation and promotion. This kind of dual-modal imaging system takes the advantage of compactness and high cost-efficiency of commercial ultrasound systems, and permits noninvasive real-time PA/US imaging simultaneously. The feasi-bility of this type of dual-modality PA/US system in the evaluation of joint disease has been explored and validated by recent studies. Moreover, exogenous contrast agents can facilitate molecular PAI in arthritis by binding specific molecules to those photoacoustic dyes, enabling visualizing inflammatory changes of local joints and delivering therapeutic agents for treating arthritis. Currently, researchers are making efforts to eliminate reflection artifacts, and to enhance the quality and speed of PAI acquisition for diagnosing inflammatory arthritis.

关键词(KeyWords)： 关节炎性疾病;光声成像;光声效应;超声成像;双模态成像
inflammatory arthritis;photoacoustic imaging;photoacoustic effect;ultrasonography;dual-model imaging

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(61971447);国家自然科学青年基金(81301268);; 科技部科技合作专项基金(2015DFA30440);; 北京市自然科学基金(JQ18023);; 北京市科技新星计划项目(Z131108000413063);; 北京市科技新星交叉合作计划项目(xxjc201812)~~

作者(Authors): 赵辰阳;朱庆莉;张睿;齐振红;杨萌;姜玉新;
ZHAO Chen-yang;ZHU Qing-li;ZHANG Rui;QI Zhen-hong;YANG Meng;JIANG Yu-xin;Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

参考文献(References)：

• [1] Minichiello E,Semerano L,Boissier MC.Time trends in the incidence,prevalence,and severity of rheumatoid arthritis:A systematic literature review[J].Joint Bone Spine,2016,83:625- 630.
• [2] Prieto-Alhambra D,Judge A,Javaid MK,et al.Incidence and risk factors for clinically diagnosed knee,hip and hand osteoarthritis:influences of age,gender and osteoarthritis affecting other joints[J].Ann Rheum Dis,2014,73:1659- 1664.
• [3] Smolen JS,Breedveld FC,Burmester GR,et al.Treating rheumatoid arthritis to target:2014 update of the recommendations of an international task force[J].Ann Rheum Dis,2016,75:3- 15.
• [4] Arnett FC,Edworthy SM,Bloch DA et al.The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis[J].Arthritis Rheum,1988,31:315- 324.
• [5] ?stergaard M,Boesen M.Imaging in rheumatoid arthritis:the role of magnetic resonance imaging and computed tomography[J].Radiol Med,2019,124:1128- 1141.
• [6] Ciurtin C,Jones A,Brown G,et al.Real benefits of ultrasound evaluation of hand and foot synovitis for better characterisation of the disease activity in rheumatoid arthritis[J].Eur Radiol,2019,29:6345- 6354.
• [7] Zhao CY,Jiang YX,Li JC,et al.Role of Contrast-enhanced Ultrasound in the Evaluation of Inflammatory Arthritis[J].Chin Med J (Engl),2017,130:1722- 1730.
• [8] Chamberland D,Jiang YB,Wang XD.Optical imaging:new tools for arthritis[J].Integr Biol (Camb),2010,2:496- 509.
• [9] Zhao CY,Xiao MS,Jiang YX,et al.Feasibility of computer-assisted diagnosis for breast ultrasound:the results of the diagnostic performance of S-detect from a single center in China[J].Cancer Manag Res,2019,11:921- 930.
• [10] Attia ABE,Balasundaram G,Moothanchery M,et al.A review of clinical photoacoustic imaging:Current and future trends[J].Photoacoustics,2019,16:100144.
• [11] Wang LV,Gao L.Photoacoustic microscopy and computed tomography:from bench to bedside[J].Annu Rev Biomed Eng,2014,16:155- 185.
• [12] Xia J,Yao JJ,Wang LV.Photoacoustic tomography:principles and advances[J].Electromagn Waves (Camb),2014,147:1- 22.
• [13] Wang S,Lin J,Wang TF,et al.Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications[J].Theranostics,2016,6:2394- 2413.
• [14] Yu J,Nguyen HNY,Steenbergen W,et al.Recent Development of Technology and Application of Photoacoustic Molecular Imaging Toward Clinical Translation[J].J Nucl Med,2018,59:1202- 1207.
• [15] Wang X,Chamberland DL,Carson PL,et al.Imaging of joints with laser-based photoacoustic tomography:an animal study[J].Med Phys,2006,33:2691- 2697.
• [16] Wang X,Chamberland DL,Jamadar DA.Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis[J].Opt Lett,2007,32:3002- 3004.
• [17] Chamberland DL,Wang X,Roessler BJ.Photoacoustic tomography of carrageenan-induced arthritis in a rat model[J].J Biomed Opt,2008,13:011005.
• [18] Sun Y,Jiang HB.Quantitative three-dimensional photoacoustic tomography of the finger joints:phantom studies in a spherical scanning geometry[J].Phys Med Biol,2009,54:5457- 5467.
• [19] Sun Y,Sobel E,Jiang HB.Quantitative three-dimensional photoacoustic tomography of the finger joints:an in vivo study[J].J Biomed Opt,2009,14:064002.
• [20] Yuan Z,Jiang HB.Three-dimensional finite-element-based photoacoustic tomography:Reconstruction algorithm and simulations[J].Med Phys,2007,34:538- 546.
• [21] Sun Y,Sobel ES,Jiang HB.First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints[J].Med Phys,2011,38:4009- 4017.
• [22] van Es P,Biswas SK,Bernelot Moens HJ,et al.Initial results of finger imaging using photoacoustic computed tomography[J].J Biomed Opt,2014,19:060501.
• [23] Ermilov S,Su R,Zamora M,et al.Optoacoustic angiography of peripheral vasculature[J].Proc Spie,2012,8223:8.
• [24] Liu YB,Wang YT,Yuan Z.Dual-Modality Imaging of the Human Finger Joint Systems by Using Combined Multispectral Photoacoustic Computed Tomography and Ultrasound Computed Tomography[J].Biomed Res Int,2016,2016:1453272.
• [25] Oeri M,Bost W,Sénégond N,et al.Hybrid Photoacoustic/Ultrasound Tomograph for Real-Time Finger Imaging[J].Ultrasound Med Biol,2017,43:2200- 2212.
• [26] Wang XD,Fowlkes JB,Cannata JM,et al.Photoacoustic imaging with a commercial ultrasound system and a custom probe[J].Ultrasound Med Biol,2017,37:484- 492.
• [27] Rajian JR,Girish G,Wang XD.Photoacoustic tomography to identify inflammatory arthritis[J].J Biomed Opt,2012,17:96013- 96021
• [28] Rajian JR,Shao X,Chamberland DL,et al.Characteriza-tion and treatment monitoring of inflammatory arthritis by photoacoustic imaging:a study on adjuvant-induced arthritis rat model[J].Biomed Opt Express,2013,4:900- 908.
• [29] Xu G,Rajian JR,Girish G,et al.Photoacoustic and ultrasound dual-modality imaging of human peripheral joints[J].J Biomed Opt,2013,18:10502.
• [30] Daoudi K,van den Berg PJ,Rabot O,et al.Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging[J].Opt Express,2014,22:26365- 26374.
• [31] van den Berg PJ,Daoudi K,Bernelot Moens HJ,et al.Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system[J].Photoacoustics,2017,8:8- 14
• [32] Yuan J,Xu G,Yu Y,et al.Real-time photoacoustic and ultrasound dual-modality imaging system facilitated with graphics processing unit and code parallel optimization[J].J Biomed Opt,2013,18:86001.
• [33] Jo J,Xu G,Cao M,et al.A Functional Study of Human Inflammatory Arthritis Using Photoacoustic Imaging[J].Sci Rep,2017,7:15026.
• [34] Zhu YH,Xu G,Yuan J,et al.Light Emitting Diodes based Photoacoustic Imaging and Potential Clinical Applications[J].Sci Rep,2018,8:9885.
• [35] Yang M,Zhao LY,He XJ,et al.Photoacoustic/ultrasound dual imaging of human thyroid cancers:an initial clinical study[J].Biomed Opt Express,2017,8:3449- 3457.
• [36] Xi L,Jiang HB.Integrated photoacoustic and diffuse optical tomography system for imaging of human finger joints in vivo[J].J Biophotonics,2016,9:213- 217.
• [37] Chamberland DL,Agarwal A,Kotov N,et al.Photoacoustic tomography of joints aided by an Etanercept-conjugated gold nanoparticle contrast agent-an ex vivo preliminary rat study[J].Nanotechnology,2008,19:095101.
• [38] Ray A,Yoon HK,Koo Lee YE,et al.Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy[J].Analyst,2013,138:3126- 3130.
• [39] Beziere N,von Schacky C,Kosanke Y,et al.Optoacoustic imaging and staging of inflammation in a murine model of arthritis[J].Arthritis Rheumatol,2014,66:2071- 2078.
• [40] Keswani RK,Tian C,Peryea T,et al.Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent[J].Sci Rep,2016,6:23528.
• [41] Ukai T,Sato M,Ishihara M,et al.Usefulness of using laser-induced photoacoustic measurement and 3.0 Tesla MRI to assess knee cartilage damage:a comparison study[J].Arthritis Res Ther,2015,17:383.
• [42] Biswas SK,van Es P,Steenbergen W,et al.A Method for Delineation of Bone Surfaces in Photoacoustic Computed Tomography of the Finger[J].Ultrason Imaging,2016,38:63- 76.