协和医学杂志

2019, v.10(01) 73-76

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如何利用临床资料进行回顾性队列研究
How to Use Clinical Data to Do Retrospective Cohort Study?

王小钦;
WANG Xiao-qin;Evidence-based Medicine Centre of Fudan University;Department of Hematology,Huashan Hospital,Fudan University;

摘要(Abstract):

临床病例资源丰富,但往往存在基线资料不全、非随机分组导致混杂因素多、失访率高等问题,限制了临床医生利用这些数据开展研究。采用限制、配对、分层、多因素分析、倾向性评分等多种方法可以克服已有临床病例资料的固有缺陷,从而得出可靠结论。本文从队列研究的设计、分析、论文撰写等方面阐述如何进行高质量的临床研究。
Clinical data are abundant,but there are some problems that limit clinicians' use of these data for clinical research,such as incomplete baseline data,confounding bias due to nonrandom grouping,and higher loss of follow-up. The inherent defects of retrospective design can be overcome by limitations,matching,stratification,multivariate analysis,propensity score,and other methods. This article elaborated how to do a high-quality cohort study from the perspectives of design,analysis and paper writing.

关键词(KeyWords): 临床研究;回顾性队列研究;混杂因素;倾向性评分
clinical research;retrospective cohort study;confounding factors;propensity score analysis

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基金项目(Foundation): 上海市自然科学基金(16ZR1404400)

作者(Author): 王小钦;
WANG Xiao-qin;Evidence-based Medicine Centre of Fudan University;Department of Hematology,Huashan Hospital,Fudan University;

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