协和医学杂志

2012, v.3(01) 68-71

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肝细胞异型增生结节的临床病理
Clinicopathological Observation on Hepatocellular Dysplastic Nodules

周炜洵;梁智勇;刘彤华;
ZHOU Wei-xun,LIANG Zhi-yong,LIU Tong-hua Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

摘要(Abstract):

目的探讨肝细胞异型增生结节的病理特点及诊断要点。方法收集12例肝细胞异型增生病例,总结、分析其病理改变及其临床资料。结果肝细胞异型增生多为肉眼能识辨的结节,以增生的肝细胞密度增加、核/浆比增高为特点,可伴有肝细胞排列紊乱及非配比小动脉的出现。2例病例出现早期肝细胞肝癌的表现。临床随诊7例手术切除后无再发,1例48个月后发生肝癌。结论肝细胞异型增生结节病理形态学有其特点,与肝细胞肝癌关系密切,是肝细胞肝癌的癌前病变。
Objective To discuss the clinicopathological characteristics of hapatocellular dysplastic nodules.Methods Totally 12 cases of hepatocellular dysplastic nodules were collected and their clinical and pathological features were reviewed.Results Hepatocellular dysplastic nodules were shown as nodules on gross examination.On microscopic examination,they showed increased cell density as well as nucleus/cytoplasm ratio.Structural atypia and unpaired arteries were also found.In 2 cases there were foci of early hepatocellular carcinoma in dysplastic nodules.During the follow-up,7 patients lived without tumors,and 1 patient developed hepatocellular carcinoma after 48 months.Conclusion Hepatocellular dysplastic nodules have typical clinicopathology and can be regarded as a precursor of hapatocellular carcinoma.

关键词(KeyWords): 肝疾病;异型增生;诊断
liver diseases;dysplastic;diagnosis

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作者(Author): 周炜洵;梁智勇;刘彤华;
ZHOU Wei-xun,LIANG Zhi-yong,LIU Tong-hua Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

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