左亚刚;王宏伟;王家璧;
ZUO Ya-gang,WANG Hong-wei,WANG Jia-bi Department of Dermatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

• 1:中国医学科学院 北京协和医学院 北京协和医院皮肤科

摘要(Abstract)：

目的评价双波长595nm和1064nm激光器治疗难治性鲜红斑痣的疗效和安全性。方法回顾性分析北京协和医院皮肤科激光中心2009年1月至2011年12月间采用双波长595nm和1064nm激光器治疗16例对传统脉冲染料激光治疗抵抗的难治性鲜红斑痣患者的资料,评价其疗效和安全性。结果 16例患者中2例痊愈,6例显效,6例有效,2例无效。3例患者出现水疱,2例出现瘢痕,无其他不良反应发生。结论双波长595nm和1064nm激光器对难治性鲜红斑痣疗效显著,不良反应较少。
Objective To evaluate the effectiveness and safety of dual-wavelength laser in treating the resistant port-wine stains (PWS).Methods Sixteen patients with single wavelength pulsed dye laser (PDL)-resistant PWS were subsequently treated with a dual-wavelength laser (595 nm and 1064 nm combination) in our department from January 2009 to December 2011.Their outcomes were recorded and retrospectively analyzed.Results Of the 16 patients,2 were cured,6 markedly effective,6 effective,and 2 ineffective.Vesicu-lation and scarring were seen in 3 and 2 patients,respectively,whereas no other adverse effects were reported.Conclusion The novel dual-wavelength (595 nm and 1064 nm) laser is an effective and safe device for PWS that is resistant to PDL therapy alone.

关键词(KeyWords)： 双波长;脉冲染料激光;掺钕钇铝石榴石激光;鲜红斑痣
dual wavelength;pulsed dye laser;neodymium-doped yttrium aluminum garnet laser;port-wine stains

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 左亚刚;王宏伟;王家璧;
ZUO Ya-gang,WANG Hong-wei,WANG Jia-bi Department of Dermatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

Email:

DOI:

参考文献(References)：

• [1]Lorenz S,Maier C,Segerer H,et al.Skin changes in new-born infants in the first5days of life[J].Hautarzt,2000,51:396-400.
• [2]Jacobs AH,Walton RG.The incidence of birthmarks in the neonate[J].Pediatrics,1976,58:218-222.
• [3]Faurschou A,Olesen AB,Leonardi-Bee J,et al.Lasers or light sources for treating port-wine stains[J].Cochrane Da-tabase Syst Rev,2011,(11):CD007152.
• [4]Shah S,Alster TS.Laser treatment of dark skin:an updated review[J].Am J Clin Dermatol,2010,11:389-397.
• [5]Viator JA,Au G,Paltauf G,et al.Clinical testing of a pho-toacoustic probe for port wine stain depth determination[J].Lasers Surg Med,2002,30:141-148.
• [6]Izikson L,Nelson JS,Anderson RR.Treatment of hyper-trophic and resistant port wine stains with a755nm laser:a case series of20patients[J].Lasers Surg Med,2009,41:427-432.
• [7]Alster TS,Tanzi EL.Combined595-nm and1,064-nm laser irradiation of recalcitrant and hypertrophic port-wine stains in children and adults[J].Dermatol Surg,2009,35:914-919.
• [8]左亚刚,王家璧,姜国调,等.585nm脉冲染料激光治疗鲜红斑痣2317例回顾性分析[J].中国医学科学院学报,2006,28:206-209.
• [9]Whang KK,Byun JY,Kim SH.A dual-wavelength approach with585nm pulsed-dye laser and800nm diode laser fortreatment-resistant port-wine stains[J].Clin Exp Dermatol,2009,34:e436-e437.
• [10]Edstrom DW,Ros AM.The treatment of port-wine stains with the pulsed dye laser at600nm[J].Br J Dermatol,1997,136:360-363.
• [11]Peters MA,van Drooge AM,Wolkerstorfer A,et al.Double pass595nm pulsed dye laser at a6minute interval for the treatment of port-wine stains is not more effective than single pass[J].Lasers Surg Med,2012,44:199-204.
• [12]Frohm Nilsson M,Passian S,Wiegleb Edstrom D.Compari-son of two dye lasers in the treatment of port-wine stains[J].Clin Exp Dermatol,2010,35:126-130.
• [13]Yang MU,Yaroslavsky AN,Farinelli WA,et al.Long-pulsed neodymium:yttrium-almuminum-garnet laser treat-ment of deep cutaneous vascular lesions[J].Dermatol Surg,2003,29:35-42.