王广健;王小亭;
WANG Guangjian;WANG Xiaoting;Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

• 1:中国医学科学院北京协和医院重症医学科

摘要(Abstract)：

随着对重症病理生理机制的不断深入探索，机体反应作为衔接不同病因与重症发生发展过程中的“桥梁”而备受关注。机体反应是重症病理生理学的热点与重点，血流动力学是重症发生发展过程中的核心与重心，二者关系极为密切：一方面，机体反应可从多个方面对血流动力学产生显著影响；另一方面，通过镇痛-镇静-抗交感治疗，炎症、免疫、凝血、代谢及生物能管理等方式干预机体反应，可稳定血流动力学，达到重症治疗的目的。加深对机体反应的认知和理解，不但丰富了重症血流动力学的内涵，而且有利于进一步研究和探索重症病理生理机制。鉴于此，本文从基于机体反应的重症新认识、机体反应对血流动力学的影响、基于机体反应的血流动力学治疗3个方面进行描述，详细阐明机体反应与血流动力学密不可分的关系。
With the continuous exploration of the pathophysiological mechanisms of critical illness, the host response, a “bridge” between different etiologies and the development of critical illness, has received much attention. Host response is the focus of critical illness pathophysiology, and hemodynamics is the core of critical illness development. On the one hand, the host response has a significant impact on hemodynamics; on the other hand, the intervention of the host response through analgesic-sedative-anti-sympathetic therapy and the management of inflammation, immunity, coagulation, metabolism, and bioenergy can stabilize the hemodynamics and achieve the goal of critical illness treatment. A deepening understanding of host response not only enriches the connotation of hemodynamics but also facilitates further study and exploration of the pathophysiological mechanisms of critical illness. Therefore, we describe host response from three aspects: a new understanding of critical illness based on host response, the effect of host response on hemodynamics, and hemodynamic therapy based on the host response.

关键词(KeyWords)： 重症;机体反应;血流动力学;宿主/机体失调反应;重症单元
critical illness;host response;hemodynamics;host/organ unregulated response;critical unit

Abstract:

Keywords:

基金项目(Foundation): 中央高水平医院临床科研业务费项目(2022-PUMCH-B-026)~~

作者(Authors): 王广健;王小亭;
WANG Guangjian;WANG Xiaoting;Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

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