协和医学杂志

2019, v.10(06) 673-678

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微小RNA调控干扰素-α在系统性红斑狼疮发病机制中的作用
The Role of MicroRNA Regulation of Interferon-α in the Pathogenesis of Systemic Lupus Erythematosus

夏源;李向培;
XIA Yuan;LI Xiang-pei;Department of Rheumatology and Immunology,the First Affiliated Hospital of University of Science and Technology of China;

摘要(Abstract):

系统性红斑狼疮是一种多系统受累的自身免疫病。干扰素-α作为系统性红斑狼疮免疫紊乱的关键因素,对其作用机制及信号通路的研究可进一步揭示系统性红斑狼疮的发病机制,并为该病的临床治疗提供新策略。近年研究发现,微小RNA在系统性红斑狼疮发病机制中具有重要作用,且微小RNA异常表达参与Ⅰ型干扰素通路的调节。本文综述了微小RNA对Ⅰ型干扰素通路的调节及其在系统性红斑狼疮发病机制中的作用,对进一步认识系统性红斑狼疮的发病机制具有重要意义。
Systemic lupus erythematosus is a multi-systemic autoimmune disease. Interferon-α is a key factor in the systemic lupus erythematosus immune disorder. The mechanism of action and signaling pathways further reveal the pathogenesis of systemic lupus erythematosus and provide a new strategy for the clinical treatment of the disease. Recent studies have found that microRNA plays an important role in the pathogenesis of systemic lupus erythematosus,and abnormal microRNA expression is involved in the regulation of type I interferon pathway. This article reviews the regulation of microRNAs on the type I interferon pathway and its role in the pathogenesis of systemic lupus erythematosus,which is of great significance for further understanding the pathogenesis of systemic lupus erythematosus.

关键词(KeyWords): 系统性红斑狼疮;微小RNA;干扰素-α
systemic lupus erythematosus;microRNA;interferon-α

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基金项目(Foundation): 国家自然科学基金(81373186)

作者(Author): 夏源;李向培;
XIA Yuan;LI Xiang-pei;Department of Rheumatology and Immunology,the First Affiliated Hospital of University of Science and Technology of China;

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