詹皓婷;李永哲;
ZHAN Haoting;LI Yongzhe;Graduate School, Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Clinical Laboratory, Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

• 1:中国医学科学院北京协和医学院研究生院
• 2:中国医学科学院北京协和医学院北京协和医院检验科侵袭性真菌病机制研究与精准诊断北京市重点实验室

摘要(Abstract)：

肿瘤相关自身抗体是由肿瘤相关抗原的异常暴露或呈递促进自身免疫反应而产生。该抗体水平可提前数月或数年于肿瘤患者体内升高,参与肿瘤恶性转化的发生与发展。近年来,肿瘤相关自身抗体的研究和应用为肿瘤的早期预警、危险评估、诊断、预后及治疗效果判断提供了重要参考依据。本文探讨肿瘤相关自身抗体产生机制、结缔组织病合并肿瘤和恶性肿瘤相关自身抗体的临床应用现状与研究进展,并对未来前景作出展望。
Tumor-associated autoantibodies are produced by abnormal exposure or presentation of tumor-associated antigen that promote autoimmune responses, elevation of which could be months or years in advance and participate in the occurrence and development of malignant transformation of tumors. In recent years, clinical application of tumor-associated autoantibodies has become increasingly prominent and provided a reference for early warning, risk assessment, diagnosis, prognosis and therapeutic efficacy in patients with cancer. This review mainly focused on the production mechanism, the status quo and future prospective of clinical application as well as research progress of tumor-associated autoantibodies in connective tissue diseases combined with tumors and malignancy.

关键词(KeyWords)： 肿瘤相关自身抗体;结缔组织病;恶性肿瘤;生物标志物;诊断
tumor-associated autoantibodies;connective tissue diseases;malignancy;biomarker;diagnosis

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81871302);; 北京市临床重点专科医学检验科卓越项目(ZK201000)~~

作者(Authors): 詹皓婷;李永哲;
ZHAN Haoting;LI Yongzhe;Graduate School, Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Clinical Laboratory, Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College;

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