姜旭;杨华夏;张奉春;
JIANG Xu;YANG Huaxia;ZHANG Fengchun;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,National Clinical Research Center for Dermatologic and Immunologic Diseases,Ministry of Education Key Laboratory;

• 1:中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室
• 2:中国医学科学院北京协和医院风湿免疫科国家皮肤与免疫疾病临床医学研究中心风湿免疫病学教育部重点实验室

摘要(Abstract)：

肠道菌群及其代谢产物在维持宿主免疫稳态方面具有重要作用，肠道菌群紊乱及代谢产物异常与多种自身免疫疾病的发生发展密切相关。肠道菌群代谢产物中，短链脂肪酸、色氨酸及其衍生物、胆汁酸的研究最为广泛。本文将重点阐述肠道菌群代谢产物的形成途径、对免疫应答的影响及与自身免疫性疾病的关联等，解析其在自身免疫疾病中的作用。
The gut microbiota and their metabolites play a critical role in the maintenance of host immune homeostasis. The dysbiosis and gut microbiota-derived metabolites are closely associated with the initiation and development of multiple autoimmune diseases. Among the microbiota metabolites, short-chain fatty acids, tryptophan and its derivatives, and bile acids are the most widely studied. In this review, the metabolic pathway of the microbiota metabolites, their functions in the immune response and the current findings on their correlation with autoimmune diseases are summarized, with the hope of revealing the role of gut microbiota-derived metabolites on the pathogenesis of autoimmune diseases.

关键词(KeyWords)： 肠道菌群代谢产物;自身免疫性疾病;短链脂肪酸;色氨酸;胆汁酸
gut microbial metabolites;autoimmune diseases;short chain fatty acids;tryptophan;bile acids

Abstract:

Keywords:

基金项目(Foundation): 中国医学科学院医学与健康科技创新工程(2020-I2M-C&T-B-011,2021-I2M-1-016);; 国家自然科学基金(82171799)~~

作者(Authors): 姜旭;杨华夏;张奉春;
JIANG Xu;YANG Huaxia;ZHANG Fengchun;State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,National Clinical Research Center for Dermatologic and Immunologic Diseases,Ministry of Education Key Laboratory;

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