协和医学杂志

2020, v.11(05) 596-600

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幽门螺旋杆菌感染与子痫前期的关系
Relationship between Helicobacter Pylori and Preeclampsia

余婷;彭芸花;
YU Ting;PENG Yun-hua;First Clinical Medical College of Lanzhou University;Department of Gynaecology and Obstetrics,The Second Affiliated Hospital of Hainan Medical University;

摘要(Abstract):

幽门螺旋杆菌是最常见的消化道致病菌,参与急性胃肠炎、消化性溃疡、胃肠肿瘤等胃肠道疾病的发生发展,与胃肠外疾病也有密切联系。研究发现,幽门螺旋杆菌感染与子痫前期存在明确的流行病学因果关系,特别是细胞毒素相关基因A(cytotoxin-associated gene A, cagA)阳性的幽门螺旋杆菌菌株诱导产生的抗cagA抗体可与滋养层细胞发生免疫反应导致滋养细胞浸润异常。此外,幽门螺旋杆菌感染引起的炎症反应、脂质代谢异常可造成血管内皮功能异常,导致子痫前期。本文将对幽门螺旋杆菌感染与子痫前期的关系作一综述。
Helicobacter pylori is one of the most common pathogenic bacteria of the digestive tract, which is involved in the etiology of acute gastroenteritis, peptic ulcer, gastrointestinal tumor and Parenteral diseases. The epidemiological relationship between Helicobacter pylori and preeclampsia has been confirmed currently. Even tighter association has been found between preeclampsia and infection of cytotoxin-associated gene A(cagA) positive strains of Helicobacter pylori. The anti-caga antibody induced by Helicobacter pylori can have an immune reaction with trophoblast cells, leading to abnormal trophoblast infiltration. In addition, the inflammation and abnormal lipid metabolism caused by Helicobacter pylori can cause abnormal vascular endothelial function, leading to the onset of preeclampsia and the generation of long-term complications. This article reviews the relationship between Helicobacter pylori and preeclampsia and the latest research progress.

关键词(KeyWords): 幽门螺旋杆菌;子痫前期;抗细胞毒素相关基因A抗体
Helicobacter pylori;preeclampsia;anti-cagA antibody

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作者(Author): 余婷;彭芸花;
YU Ting;PENG Yun-hua;First Clinical Medical College of Lanzhou University;Department of Gynaecology and Obstetrics,The Second Affiliated Hospital of Hainan Medical University;

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